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Regardless of whether they are obese or not, adults with diabetes are at increased risk of developing severe illness after being infected with the new coronavirus
.
In type 2 diabetic patients, fat distribution is characterized by the expansion of visceral and ectopic adipose tissue, leading to systemic inflammation, which may be involved in the occurrence of cytokine storm when the new coronary pneumonia ( COVID-19 ) is promoted
Diabetes infection In patients with type 2 diabetes, fat distribution is characterized by the expansion of visceral and ectopic adipose tissue, leading to systemic inflammation, which may be involved in the occurrence of cytokine storm when the new coronary pneumonia ( COVID-19 ) is promoted
The purpose of the study is to determine whether the levels of interleukin-6 (IL-6) in cardiac adipose tissue can predict short-term adverse outcomes, deaths, and ICU needs of COVID-19 diabetic patients within 21 days after admission
.
81 patients with type 2 diabetes who were hospitalized due to COVID-19 were included
.
Upon admission, IL-6 levels were detected and chest CT with a total cardiac adipose tissue index (CATi) measurement value was performed
CATi and IL-6 levels of patients grouped according to short-term prognosis
CATi and IL-6 levels of patients grouped according to short-term prognosisThe median age of the tested patients was 66 years old, 73% were males, and the median body mass index (BMI) was 27 kg/m2.
20 patients died of COVID-19, 20 patients needed to be admitted to the ICU, and 41 patients were admitted to the hospital Receive routine care on the 21st day
.
Increased levels of CATi and IL-6 are associated with an increase in early mortality (OR 6.
Increased levels of CATi and IL-6 are associated with an increase in early mortality (OR 6.
Based on CATi and IL-6 to predict the performance of patients with short-term mortality risk and ICU needs
Based on CATi and IL-6 to predict the performance of patients with short-term mortality risk and ICU needsResearchers combined CATi and IL-6 levels as the multiplicative interaction score (CATi*IL-6)
.
When the cut-off value of the score is ≥6386 points, the sensitivity is 0.
Researchers combined CATi and IL-6 levels as the multiplicative interaction score (CATi*IL-6)
The determination of cardiac adipose tissue index and IL-6 in diabetic patients admitted to the hospital due to new coronary pneumonia can help doctors better identify patients with a high short-term risk of rapid deterioration and early death
Original source:
Phan, F.
Cardiac adipose tissue volume and IL-6 level at admission are complementary predictors of severity and short-term mortality in COVID-19 diabetic patients in this message
