Cardiovasc Diabetol: C-peptide levels can predict cardiovascular disease risk in diabetic patients

Low C-peptide levels indicate β-cell dysfunction, which is related to daytime blood glucose variation and increased risk of hypoglycemia
.

In the late stage type 2 diabetes patients, severe hypoglycemia and glycemic variability increases can predict heart vascular disease (CVD) risk

Hypoglycemia diabetic blood vessel

This study evaluated the correlation between C-peptide levels and cardiovascular disease risk, and whether it could be explained by changes in blood glucose between visits and severe hypoglycemia
.

Researchers evaluated fasting C-peptide levels at baseline, composite cardiovascular disease outcomes, severe hypoglycemia, and inter-visit fasting blood glucose coefficient of variation (CV) and average actual variation in 1565 Veterans Affairs diabetes trial participants Sex (ARV)
.

Correlation between C peptide level and cardiovascular disease risk

Correlation between C peptide level and cardiovascular disease risk

The analysis results show that there is a "U" type correlation between C peptide and cardiovascular disease risk .
In the low range (<0.
50 nmol/l), the cardiovascular disease risk increases with the decrease of C peptide level (1.
30, p =0.
02); in the high range (>1.
23 nmol/l), the risk of cardiovascular disease increases with the increase of C-peptide level (1.
27, p=0.
05)
.

There is a "U" type correlation between C peptide and cardiovascular disease risk There is a "U" type correlation between C peptide and cardiovascular disease risk

Correlation between C peptide level and severe hypoglycemia

Correlation between C peptide level and severe hypoglycemia

The C-peptide level was negatively correlated with the risk of severe hypoglycemia and inter-visit blood glucose variability (OR: hypoglycemia: 0.
68; CV: -0.
12; ARV: -0.
10; p<0.
0001)
.

The correlation between low C-peptide levels and cardiovascular disease risk was not related to cardiometabolic risk factors (1.

C-peptide level is negatively correlated with severe hypoglycemia risk and inter-visit blood glucose variability C-peptide level is negatively correlated with severe hypoglycemia risk and inter-visit blood glucose variability

Low (<0.
50 nmol/l) and high (>1.
23 nmol/l) C-peptide levels and the risk ratio of cardiovascular disease

Low (<0.
50 nmol/l) and high (>1.
23 nmol/l) C-peptide levels and the risk ratio of cardiovascular disease

In conclusion, low C-peptide levels are associated with an increased risk of cardiovascular disease in patients with advanced type 2 diabetes
.

This correlation has nothing to do with the increase in glucose variation or severe hypoglycemia

Low C-peptide levels are associated with an increased risk of cardiovascular disease in patients with advanced type 2 diabetes.

Original source:

Koska, J.

Association of low fasting C-peptide levels with cardiovascular risk, visit-to-visit glucose variation and severe hypoglycemia in the Veterans Affairs Diabetes Trial (VADT) in this message