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Cardiovasc Diabetol: Correlation between plasma metabolites and subclinical atherosclerosis in patients with type 2 diabetes

 Last Update: 2021-12-27
 Source: Internet
 Author: User

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Heart vascular disease (CVD) incidence is increasing, partly because diabetes epidemic
.

Therefore, new predictive tools and modifiable treatment targets are needed to strengthen risk assessment and management

Heart vascular disease vascular (CVD) incidence is increasing, partly because diabetes epidemic

The analysis included 700 Ming DHS participants, 438 African-Americans who (AAs) and 262 Ming European Americans (EAs) , which coronary artery calcification (CAC) using ECG gating ct evaluated
.

Plasma metabolomics using liquid chromatography - mass spectrometry identified 853 known metabolites

The analysis included 700 Ming DHS participants, 438 African-Americans who (AAs) and 262 Ming European Americans (EAs) , which coronary artery calcification (CAC) using ECG gating ct evaluated

The data shows that when the FDR corrected p value is less than 0.
05 , 33 metabolites in AAs are related to CAC , and 36 metabolites in EAs are related to CAC .
Androgen, fatty acid, phosphatidylcholine and bile acid metabolic pathways are related to androgen, fatty acid, phosphatidylcholine and bile acid metabolic pathways and androgen, fatty acid, phosphatidylcholine and bile acid metabolic pathways are related to CAC in AAs, The fatty acid, lysogen, and branched chain amino acid (BCAA) pathways are related to CAC in EAs .

The figure above shows the correlation between plasma metabolites in AA and CAC
.

The model was adjusted according to age, gender, BMI, smoking status, hypertension status, cardiovascular disease, diabetes course, plasma collection date, time between plasma collection and CT examination, LDL-C, and statin use

The figure above shows the correlation between plasma metabolites in AA and CAC

The figure above shows the correlation between plasma metabolites in EA and CAC
.

The figure above shows the correlation between plasma metabolites in EA and CAC

As described above, in the in AA and EA DHS participants, different metabolic characteristics significantly associated with subclinical coronary atherosclerosis

The level of CAC in European populations is much higher than that of AA , and the risk of myocardial infarction will increase when the accessibility of healthcare between the populations is the same

References: Chevli, PA, Freedman, BI, Hsu, FC.
et al.
Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.
Cardiovasc Diabetol 20,231 (2021).
https://doi.
org/10.
1186/s12933 -021-01419-y Chevli, PA, Freedman, BI, Hsu, FC.
et al.
Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.
Cardiovasc Diabetol 20, 231 (2021).
https://doi.
org/ 10.
1186/s12933-021-01419-y https://doi.
org/10.
1186/s12933-021-01419-y Leave a message here

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