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    Home > Active Ingredient News > Endocrine System > Cardiovasc Diabetol: Correlation between triglyceride glucose index and carotid plaque in patients with coronary heart disease under different glucose metabolism status

    Cardiovasc Diabetol: Correlation between triglyceride glucose index and carotid plaque in patients with coronary heart disease under different glucose metabolism status

    • Last Update: 2022-05-13
    • Source: Internet
    • Author: User
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    Background: Coronary heart disease (CHD) is a chronic non-communicable disease (NCD) with extremely high morbidity and mortality
    .
    Diabetes often coexists with arterial hypertension and dyslipidemia

    .
    Type 2 diabetes (T2DM) accounts for 95% of all diseases diagnosed with diabetes

    .
    This is one of the risk factors for coronary artery disease (CAD) and the development and rupture of atherosclerotic plaques

    .
    Coronary heart disease is also a common comorbidity and leading cause of death in patients with diabetes
    .
    The study showed that in participants without a history of coronary heart disease, T2DM was associated with carotid plaque (CAP), a better predictor than high carotid intima-media thickness (CIMT) or recurrent cardiovascular events
    .
    People with prediabetes are prone to developing diabetes

    .
    Many studies have reported that patients with coronary heart disease have a higher risk of poor prognosis in prediabetes and disorders of glucose metabolism

    .

    Background: Coronary heart disease (CHD) is a chronic non-communicable disease (NCD) with extremely high morbidity and mortality
    .
    Diabetes often coexists with arterial hypertension and dyslipidemia

    .
    Type 2 diabetes (T2DM) accounts for 95% of all diseases diagnosed with diabetes

    .
    This is one of the risk factors for coronary artery disease (CAD) and the development and rupture of atherosclerotic plaques

    .
    Coronary heart disease is also a common comorbidity and leading cause of death in patients with diabetes
    .
    The study showed that in participants without a history of coronary heart disease, T2DM was associated with carotid plaque (CAP), a better predictor than high carotid intima-media thickness (CIMT) or recurrent cardiovascular events
    .
    People with prediabetes are prone to developing diabetes

    .
    Many studies have reported that patients with coronary heart disease have a higher risk of poor prognosis in prediabetes and disorders of glucose metabolism

    .
    Coronary heart disease is a chronic non-communicable disease (NCD) with high morbidity and mortality
    .
    Diabetes often coexists with arterial hypertension and dyslipidemia

    .
    Type 2 diabetes (T2DM) accounts for 95% of all diseases diagnosed with diabetes

    .
    This is one of the risk factors for coronary artery disease (CAD) and the development and rupture of atherosclerotic plaques

    .
    The study showed that in participants without a history of coronary heart disease, T2DM was associated with carotid plaque (CAP), a better predictor than high carotid intima-media thickness (CIMT) or recurrent cardiovascular events
    .
    People with prediabetes are prone to developing diabetes

    .
    Many studies have reported that patients with coronary heart disease have a higher risk of poor prognosis in prediabetes and disorders of glucose metabolism

    .

    The triglyceride glucose (TyG) index is a valuable biomarker for the development of diabetes and is used as a marker of insulin resistance (IR), leading to the development of NCD
    .
    The TyG index is associated with a high prevalence of coronary heart disease, while an increased risk of major adverse cardiovascular and cerebrovascular events (mace) including ischemic stroke, increased arterial stiffness, hypertension, coronary stenosis and carotid atherosclerosis Sclerosis (AS) is associated with morbidity

    .
    However, no relevant studies have investigated the relationship between TyG index and CAP according to the glucose metabolism status of patients with coronary heart disease
    .

    The triglyceride glucose (TyG) index is a valuable biomarker for the development of diabetes and is used as a marker of insulin resistance (IR), leading to the development of NCD
    .
    The TyG index is associated with a high prevalence of coronary heart disease, while an increased risk of major adverse cardiovascular and cerebrovascular events (mace) including ischemic stroke, increased arterial stiffness, hypertension, coronary stenosis and carotid atherosclerosis Sclerosis (AS) is associated with morbidity

    .
    However, no relevant studies have investigated the relationship between TyG index and CAP according to the glucose metabolism status of patients with coronary heart disease
    .
    The triglyceride glucose (TyG) index is a valuable biomarker for the development of diabetes and is used as a marker of insulin resistance (IR), leading to the development of NCD
    .
    The TyG index is associated with a high prevalence of coronary heart disease, while an increased risk of major adverse cardiovascular and cerebrovascular events (mace) including ischemic stroke, increased arterial stiffness, hypertension, coronary stenosis and carotid atherosclerosis Sclerosis (AS) is associated with morbidity

    .

    Objective: This study aimed to clarify the relationship between TyG index and CAP in patients with coronary heart disease under different glucose metabolism status, and to further study the relationship between TyG index and CAP in different gender and age stratification
    .
    In the clinical treatment of coronary heart disease, simple biochemical markers need to be identified to prevent the risk of AS (eg, CAP)

    .

    Objective: This study aimed to clarify the relationship between TyG index and CAP in patients with coronary heart disease under different glucose metabolism status, and to further study the relationship between TyG index and CAP in different gender and age stratification
    .
    In the clinical treatment of coronary heart disease, simple biochemical markers need to be identified to prevent the risk of AS (eg, CAP)

    .

    Methods: 10,535 patients with coronary heart disease were analyzed according to the quartile method of TyG index (Q1: TyG index < 8.
    52; Q2: 8.
    52 ≤ TyG index < 8.
    93; Q3: 8.
    93 ≤ TyG index ≤ 9.
    40; Q4: TyG index > 9.
    40)

    .
    Carotid ultrasonography to determine the presence or absence of CAP

    .
    Logistic regression was used to analyze the relationship between TyG index and angina pectoris in patients with coronary heart disease

    .
    The relationship between TyG index and CAP was also assessed according to gender, age group and glucose metabolism status

    .

    Methods: 10,535 patients with coronary heart disease were analyzed according to the quartile method of TyG index (Q1: TyG index < 8.
    52; Q2: 8.
    52 ≤ TyG index < 8.
    93; Q3: 8.
    93 ≤ TyG index ≤ 9.
    40; Q4: TyG index > 9.
    40)

    .
    Carotid ultrasonography to determine the presence or absence of CAP

    .
    Logistic regression was used to analyze the relationship between TyG index and angina pectoris in patients with coronary heart disease

    .
    The relationship between TyG index and CAP was also assessed according to gender, age group and glucose metabolism status

    .

    Results: Baseline analysis showed that patients with coronary heart disease were divided into four groups according to the quartiles of the TyG index, with significant differences in related parameters
    .
    In the multiple adjusted model, the odds ratio (OR) for TyG index Q4 compared with TyG index Q1 was 1.
    37 (95% confidence interval [CI] 1.
    28–1.
    47) in CHD patients

    .
    The association between TyG index and CAP was higher in women (OR: 1.
    35; 95% CI 1.
    29–1.
    43) than in men (OR: 1.
    20; 95% CI 1.
    13–1.
    27)

    .
    The OR value of middle-aged (≤60 years) patients (OR: 1.
    34; 95% CI 1.
    26–1.
    42) was higher than that of elderly (> 60 years) patients (OR: 1.
    16; 95% CI 1.
    11–1.
    22)

    .
    The TyG index was significantly associated with the risk of CAP in patients with coronary heart disease, with the highest OR value observed in diabetes mellitus (OR: 1.
    36; 95% confidence interval, 1.
    26–1.
    46) across different glucose metabolism states

    .

    Results: Baseline analysis showed that patients with coronary heart disease were divided into four groups according to the quartiles of the TyG index, with significant differences in related parameters
    .
    In the multiple adjusted model, the odds ratio (OR) for TyG index Q4 compared with TyG index Q1 was 1.
    37 (95% confidence interval [CI] 1.
    28–1.
    47) in CHD patients

    .
    The association between TyG index and CAP was higher in women (OR: 1.
    35; 95% CI 1.
    29–1.
    43) than in men (OR: 1.
    20; 95% CI 1.
    13–1.
    27)

    .
    The OR value of middle-aged (≤60 years) patients (OR: 1.
    34; 95% CI 1.
    26–1.
    42) was higher than that of elderly (> 60 years) patients (OR: 1.
    16; 95% CI 1.
    11–1.
    22)

    .
    The TyG index was significantly associated with the risk of CAP in patients with coronary heart disease, with the highest OR value observed in diabetes mellitus (OR: 1.
    36; 95% confidence interval, 1.
    26–1.
    46) across different glucose metabolism states

    .

    Table 1 Association between TyG index and carotid plaque risk

    Table 1 Association between TyG index and carotid plaque risk

    Table 2 Relationship between TyG index and carotid plaque risk by sex

    Table 2 Relationship between TyG index and carotid plaque risk by sex

    Table 3 Relationship between TyG index and carotid plaque risk by age

    Table 3 Relationship between TyG index and carotid plaque risk by age

    Table 4.
    Association between TyG index and carotid plaque risk according to different glucose regulation status and gender

    Table 4.
    Association between TyG index and carotid plaque risk according to different glucose regulation status and gender

    Conclusion: The TyG index of patients with coronary heart disease is significantly correlated with CAP
    .
    Among coronary heart disease patients, the correlation between TyG index and CAP was higher in women than in men, and higher in middle-aged and elderly patients than in elderly patients

    .
    Correlation between carotid plaque and TyG index was higher in patients with coronary heart disease in the setting of diabetes.

    Conclusion: The TyG index of patients with coronary heart disease is significantly correlated with CAP
    .
    Among coronary heart disease patients, the correlation between TyG index and CAP was higher in women than in men, and higher in middle-aged and elderly patients than in elderly patients

    .
    Correlation between carotid plaque and TyG index was higher in
    patients with coronary heart disease in the presence of diabetes.
    TyG index and CAP were significantly correlated in patients with coronary heart disease

    .
    Among coronary heart disease patients, the correlation between TyG index and CAP was higher in women than in men, and higher in middle-aged and elderly patients than in elderly patients

    .
    Correlation between carotid plaque and TyG index was higher in patients with coronary heart disease in the setting of diabetes.

    Original source: Li Z, He Y, Wang S, et al.
    Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China.
    Cardiovasc Diabetol 2022 Mar 11; 21(1)

    Original source: Li Z, He Y, Wang S, et al.
    Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China.
    Cardiovasc Diabetol 2022 Mar 11; 21(1)
    Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China.
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