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    Home > Active Ingredient News > Endocrine System > Cardiovasc Diabetol: Effects of long-term metformin administration on cardiac troponin levels in diabetic patients

    Cardiovasc Diabetol: Effects of long-term metformin administration on cardiac troponin levels in diabetic patients

    • Last Update: 2022-05-11
    • Source: Internet
    • Author: User
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    Metformin has a favorable effect on cardiovascular outcomes in both new-onset and chronic type 2 diabetes .


    Metformin Diabetic Vascular

    The aim of this study was to assess changes in cardiac troponin I and T in diabetic patients treated with metformin or placebo using a post hoc analysis of the HOME trial


    The HOME trial was a randomized controlled trial that included 390 patients with chronic type 2 diabetes who were randomly assigned to receive either metformin (850 mg, 3/day) or placebo, along with insulin


    Of the 390 subjects, 196 received metformin and 194 received placebo




    The linear mixed effects regression model of this analysis did not reveal evidence of an effect on cardiac troponin I and T levels (-8.



    The study showed that metformin had no clinically relevant effect on cardiac troponin I and T levels compared with placebo


    Metformin had no clinically relevant effect on cardiac troponin I and T levels compared to placebo Metformin had no clinically relevant effect on cardiac troponin I and T levels compared with placebo

     

    Original source:

    Original source:

    Stultiens, JMG, Top, WMC, Kimenai, DM et al.


    Stultiens, JMG, Top, WMC, Kimenai, DM et al.
    Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial.
    Cardiovasc Diabetol 21, 49 (2022) .
    https://doi.
    org/10.
    1186/s12933-022-01482-z.


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