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    Home > Active Ingredient News > Endocrine System > Cardiovasc Diabetol: High fibrinogen/albumin ratio in patients with type 2 diabetes is associated with poor prognosis in patients undergoing percutaneous coronary intervention

    Cardiovasc Diabetol: High fibrinogen/albumin ratio in patients with type 2 diabetes is associated with poor prognosis in patients undergoing percutaneous coronary intervention

    • Last Update: 2022-05-13
    • Source: Internet
    • Author: User
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    Background: Inflammation plays a crucial role in the progression of coronary atherosclerosis


    Background: Inflammation plays a crucial role in the progression of coronary atherosclerosis


    Inflammation is thought to be a common precursor of atherosclerosis and diabetes


    Methods: We consecutively enrolled 10,724 patients hospitalized for coronary heart disease undergoing PCI and followed up for major adverse cardiovascular and cerebrovascular events (MACCE), including all-cause mortality, cardiac mortality, non-fatal myocardial infarction, non-fatal Ischemic stroke and unplanned coronary revascularization


    Results: 5298 patients (58.


    Figure 1 Kaplan-Meier analysis of MACCE according to different FAR levels (A), glucose metabolism status (B), and FAR levels and glucose metabolism status (C)

    Figure 1 Kaplan-Meier analysis of MACCE according to different FAR levels (A), glucose metabolism status (B), and FAR levels and glucose metabolism status (C)

    Table 1 Predictive values ​​of FAR levels and different glucose metabolic states for the primary endpoint and each component in univariate and multivariate analyses

    Table 1 Predictive values ​​of FAR levels and different glucose metabolic states for the primary endpoint and each component in univariate and multivariate analyses

    Figure 2 Hazard ratios (95% CI) for MACCE in the four groups after adjustment for age, sex, body mass index, hypertension, previous myocardial infarction, previous PCI, previous stroke, eGFR, LVEF, LM/three-vessel disease, and SYNTAX score

    Figure 2 Hazard ratios (95% CI) for MACCE in the four groups after adjustment for age, sex, body mass index, hypertension, previous myocardial infarction, previous PCI, previous stroke, eGFR, LVEF, LM/three-vessel disease, and SYNTAX score

    Figure 3 MACCE forest plots for different subgroups


    Figure 3 MACCE forest plots for different subgroups


    Conclusions: In this real cohort study, higher levels of FAR and DM were associated with poorer 5-year outcomes in patients with coronary artery disease undergoing PCI


    Original source: Wang P, Yuan D, Zhang C, et al.
    High fibrinogen-to-albumin ratio with type 2 diabetes mellitus is associated with poor prognosis in patients undergoing percutaneous coronary intervention: 5-year findings from a large cohort.
    Cardiovasc Diabetol 2022 Mar 21;21(1)High fibrinogen-to-albumin ratio with type 2 diabetes mellitus is associated with poor prognosis in patients undergoing percutaneous coronary intervention: 5-year findings from a large cohort.
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