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Cardiovasc Diabetol: High pericoronary adipose tissue density on CT angiography predicts cardiovascular events in patients with type 2 diabetes

 Last Update: 2022-05-13
 Source: Internet
 Author: User

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Background: Coronary artery disease (CAD) is the leading cause of death in patients with type 2 diabetes mellitus (T2DM)

Recently, changes in peri-coronary adipose tissue (PCAT) attenuation assessed on coronary CTA were introduced as a new indicator of inflammation

Objective: This study aimed to investigate the predictive value of PCAT reduction on prognosis in patients with type 2 diabetes mellitus (T2 DM)

Methods: 333 T2 DM patients (average age 66 years old, 211 males, average body mass index 25 kg/m2) underwent coronary CTA examination to examine coronary calcium score, pericardial fat volume, stenosis degree (luminal stenosis>50 %), plaque hypodense and/or high-risk plaque features with positive remodeling and/or punctate calcification, and PCAT attenuation

RESULTS: During a median follow-up of 4.

Figure 1 Typical case of peri-coronary adipose tissue attenuation measured by coronary CT angiography

Figure 2 Kaplan-Meier curves for cumulative incidence of cardiovascular events

Table 1 Factors associated with cardiovascular events

Figure 3 Incremental prognostic value of left anterior descending artery-pericoronary adipose tissue attenuation for predicting cardiovascular events compared with adverse coronary CTA findings

Conclusions: In patients with T2 DM who underwent clinically diagnosed coronary CTA, high density of LAD-PCAT significantly predicted cardiovascular events

Original source: Ichikawa K, Miyoshi T, Osawa K, et al.
High pericoronary adipose tissue attenuation on computed tomography angiography predicts cardiovascular events in patients with type 2 diabetes mellitus: post-hoc analysis from a prospective cohort study.
Cardiovasc Diabetol 2022 Mar 18 ;21(1) High pericoronary adipose tissue attenuation on computed tomography angiography predicts cardiovascular events in patients with type 2 diabetes mellitus: post-hoc analysis from a prospective cohort study.
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