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    Home > Active Ingredient News > Endocrine System > Cardiovasc Diabetol: Reduced miR-21/ROS/HNE levels are associated with hypoglycemia after habitual intervention

    Cardiovasc Diabetol: Reduced miR-21/ROS/HNE levels are associated with hypoglycemia after habitual intervention

    • Last Update: 2022-04-21
    • Source: Internet
    • Author: User
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    Background: Dysglycemia or prediabetes is associated with cardiovascular risk, namely cardiovascular mortality


    Dysglycemia or prediabetes is associated with cardiovascular risk, ie cardiovascular mortality


    Thus, prediabetes is associated with T2D insulin resistance (IR), overweight and obesity, which are modifiable risk factors for other cardiometabolic risk factors, such as high blood pressure -- and greater susceptibility to cardiovascular disease


    In cancer, however, strict interactions have been established between unhealthy diet and genetic susceptibility, but the impact of interactions between common genetic variants, Western diet, and life>


    Methods: 1506 subjects were screened according to Findrisc score


    Results: After HI, the miR-21/ROS/HNE axis was significantly decreased in patients with dysglycemia, and metabolic parameters such as insulin resistance, body mass index, microalbuminuria, reactive hyperemia index and skin fluorescence were improved


    Figure 1 Expression of miR-21 in plasma after habitual intervention for 1 year


    Figure 1 Expression of miR-21 in plasma after habitual intervention for 1 year


    Table 1 Characteristics of subjects with low-miR-21

    Table 1 Characteristics of subjects with low-miR-21

    Table 2 Characteristics of NR group

    Table 2 Characteristics of NR group

    Figure 2.


    Figure 2.


    HI affected epigenetic alterations associated with the miR-21 axis and confirmed the concept of reversibility of dysglycemia


    Lower miR-21/ROS/HNE levels associate with lower glycemia after habit-intervention: DIPASON study 1-year later

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