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Insulin resistance promotes the development of type 2 diabetes (T2D) and alsoHeart vascular risk factors events
.
The purpose of this study was to investigate the potential association between insulin resistance measured by estimating glucose disposal rate (eGDR) and the risk of stroke and mortality in T2D patients
diabetesHeart blood vessel aim of this study was to investigate (eGDR) as measured by the estimated glucose disposal rate of insulin resistance and T2D patients with stroke potential association between mortality and the risk of stroke
This is an observational cohort study based on a national population, including all T2D patients with complete eGDR data from the Swedish National Diabetes Registry from 2004 to 2016, and the classification is as follows: 4, 4-6, 6-8 And ≥? 8 mg/kg/min
.
The researchers calculated the crude incidence rate and 95% confidence interval (CI), and used multivariate Cox regression to estimate the hazard ratio (HR) to assess the correlation between stroke risk and mortality
Cumulative incidence of stroke in each eGDR group
Cumulative incidence of stroke in each eGDR groupIn total, 104,697 T2D patients were enrolled.
44.
5% of them were women, with an average age of 63 years
.
During a median follow-up of 5.
During a median follow-up of 5.
Risk ratio of different types of stroke
Risk ratio of different types of strokeThe attributable relative risk R2 (± SE) of each variable of eGDR and stroke is hypertension (0.
045±0.
0024), HbA1c (0.
013±0.
0014) and waist circumference (0.
006±0.
0009), respectively
.
In summary, low glucose management rate is associated with an increased risk of stroke and death in T2D patients
.
Therefore, insulin resistance seems to increase the risk of type 2 diabetes stroke, and eGDR may be used as a risk marker for stroke and death in patients with type 2 diabetes
Low glucose management rate is associated with increased risk of stroke and death in T2D patients Low glucose management rate is associated with increased risk of stroke and death in T2D patients
Original source:
Original source:Zabala, A.
Estimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study in this message