Causes of phase III clinical failure

According to incomplete statistics, since the closure of Wuhan on January 23, China has launched nearly 120 clinical trials of Chinese and Western medicine against covid19 new coronavirus Although the novel coronavirus pneumonia is now superior to the control group in a series of clinical indicators such as severe rate and lung imaging, the Biotechnology Center of the Ministry of science and technology today will be included in the new version of the new crown pneumonia treatment plan, but most of these trials will fail Today we will talk about the reasons for the three phase clinical failure in the last ten years Prior to the start of the accelerated approval system, new drugs should be listed in strict clinical trials to prove that they are safer, more effective, or more convenient to use than standard therapy, at least than placebo New drug development is very long, but similar to the professional league, it can be divided into regular season and playoffs Although the total time of preclinical, phase I and phase II clinics is very long, they can be counted as regular seasons The purpose is to select the teams who are really qualified to participate in the playoffs, and phase III is the game that really determines the quality It's obvious that if the regular season is regular, rigorous and has enough games, the really good team will be selected for the playoffs Accelerated approval has changed this pattern to some extent, because some drugs can be temporarily approved for marketing based on the results of non control trials, and then verify the advantages in the control trials, which will be discussed later.