echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > CDC20-M Suggests Genomic Instability in Glioma

    CDC20-M Suggests Genomic Instability in Glioma

    • Last Update: 2020-06-03
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Yunqiu Zhang of the Neuroscience and Brain Development Laboratory at Beijing Normal University found that CDC20 co-expression gene module (CDC20-M) significantly improved expression in glioma, which is associated with glioma GI; The findings were published in PNAS in April 2019- From the article chapter( Ref : Zhang Y, et alProc Natl Acad Sci U S A2019 Apr 2;116 (14): 6975-6984doi: 10.1073/pnas.1814060116Epub 2019 Mar 15genomic instability (GI) can cause tumor heterogeneity and promote tumor progression and resistanceThe clinical testing methods of glioma GI have not been fully studiedYunqiu Zhang of the Neuroscience and Brain Development Laboratory at Beijing Normal University found that CDC20 co-expression gene module (CDC20-M) significantly improved expression in glioma, which is associated with glioma GI; The findings were published in PNAS in April 2019the authors first used Pearson correlation coefficient analysis to screen CDC20-M in the glioma transcription group databaseThe 139 genes in CDC20-M can form protein networks and are highly correlated with cell cycle and cell differentiationCDC20-M is highly expressed in brain tissue during embryonic and early fetal developmentRat less protogliate progenitor cells (OPC) have a high concentration of CDC20-M compared to mature neurons and less protrusion glial cellsthe authors found that the CDC20-M score, or CDC20-M average expression, was an independent predictor of the prognosis of gliomaCdc20-M moderate or highly expressed glioma patients have poorer prognosisAbnormal activity may suggest GI because the CDC20-M core gene is widely involved in DNA replication, and the DNA damage response is isolated from chromosomes Gliomas expressed at moderate or high levels of CDC20-M have more copy number variation (CNV), heterogeneous missing (LOH), and mutation loads Comparing the non-integral score between different subgroups of CDC20-M, it was found that CDC20-M was associated with higher non-integral score In the vast majority of samples, chromosomal abnormalities were observed consistent with mutation loads the authors used FDA-approved AURKA inhibitor MLN8237 (Alisertib) to significantly inhibit the growth of the highly expressed glioma cell line of CDC20-M; In addition, MLN8237 significantly inhibited the growth of intracranial xenotransplant cell lines (PDX) and prolonged the survival time of mice , according to the expression of CDC20-M, you can choose the appropriate treatment plan for glioma patients AURKA in CDC20-M may be a new target for the treatment of gliomas The study shows that CDC20-M can be used for risk stratification and the development of new treatment stodgillos in glioma patients.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.