CELL: Allen releases 3D brain map of mice with single-cell resolution

Recent large-scale collaborations are producing major studies of cell types and connections in the brains of mice, collecting data across patterns, spatial scales and brain regionsThe successful integration of this data requires a standard 3D reference atlasrecently, the Allen Mouse Brain Common Coordinate Framework (CCFv3) proposed by researchers is one such resourcein 1,675 young adult C57BL/6J mice, the researchers built an average template brain with a 10 m prosthesis resolution by integrating high-resolution in-plane sequence dual photon tomography images with a 100 m z-sampling techniquethen, using multi-modal reference data, the researchers directly segmented the entire brain in three dimensions, marking each ventricle, including 43 mesothelial regions and their layers, 329 subcutaneous gray matter structures, 81 fibrous beams, and eight ventriclesCCFv3 can be used for analysis, visualization, integration of multi-modal and multi-scale 3D data sets, and publicly accessible (https://atlas.brain-map.org/)