Cell Biol Toxicol:S100A16 promotes pancreatic cancer metastasis through FGF19-mediated AKT and ERK1/2 paths

The S100 protein family gene plays an important role in many stages of tumor development.
most of the S100 genes are located at chromosome 1q21, an area of tumor that is frequently rearmed.
in this study, researchers tested the expression of the S100 family gene in paired pancreatic catheterized adenocarcinoma (PDAC) tissue and cancerous tissue, and further verified the expression of S100A16 through immunosomal chemical staining.
results showed that S100A16 was significantly increased in clinical PDAC samples.
, the researchers further demonstrated that S100A16 promotes the proliferation, migration, invasion and transfer of PDAC cells both in vitro and in vivo.
the S100A16 gene can induce PDAC cell cycle blocking in the G2/M phase and induce apoptosis.
researchers also found that the S100A16 promotes the proliferation, migration and invasion of PDAC cells through akT and ERK1/2 signaling paths in a fibroblast growth factor 19 (FGF19) dependency.
, the study shows that S100A16 is highly expressed in PDAC tissues and promotes PDAC progression through FGF19-mediated AKT and ERK1/2 signals, suggesting that S100A16 may be a promising therapeutic target for PDAC.
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