Cell Biosci: Regulation of Pseudomonas aeruginosa on alginate biosynthesis and type VI secretion system in two critically ill patients with COVID-19

Background: Novel coronavirus pneumonia has a huge impact on the health of patients, with high morbidity and mortality
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On the basis of this viral infection, alterations in the microbial ecology of the lung often exacerbate disease and increase host susceptibility to superinfection

Alterations in the microbial ecology of the lung often exacerbate disease and increase host susceptibility to superinfection

Pseudomonas aeruginosa is the top superinfection bacterium of SARS-CoV-2.

Fig.
1 Ring diagram and phylogenetic tree of LYSZa2 and LYSZa5
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LYSZa2 and LYSZa5 with other

Fig.

Figure 2 Heatmap and PCoA plot of DEGs between genetic isolates and progeny isolates
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Heatmap of significant DEGs in LYSZa3 and LYSZa2; B heatmap of significant DEGs in LYSZa6 compared to LYSZa5; C PCoA maps of DEGs based on DEGs in LYSZa3 and LYSZa2 groups using Bray Curtis dissimilarity method; Plot the D PCoA map of the LYSZa6 group and the LYSZa5 group

Figure 2 Heatmap and PCoA plot of DEGs between genetic isolates and progeny isolates

Table 1 Common gene mutations between LYSZa3 and LYSZa6

Table 1 Common gene mutations between LYSZa3 and LYSZa6

Conclusions: Our study shows that SARS-CoV-2 infection can create a more livable lung environment, allowing bacterial pathogens with genetic characteristics suitable for chronic infection to rapidly adapt and evolve
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Our study shows that SARS-CoV-2 infection can create a more livable lung environment, allowing bacterial pathogens with genetic characteristics suitable for chronic infection to rapidly adapt and evolve
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Original source: Qu J, Cai Z, Duan X, et al.

Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patients.
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