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    Home > Active Ingredient News > Study of Nervous System > Cell breakthrough: Luo Liqun's laboratory uses in vivo imaging to reveal the developmental mechanism of the olfactory neural circuit in Drosophila

    Cell breakthrough: Luo Liqun's laboratory uses in vivo imaging to reveal the developmental mechanism of the olfactory neural circuit in Drosophila

    • Last Update: 2021-10-01
    • Source: Internet
    • Author: User
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    Source| Xiaoke Life During the development of the brain, a large number of neurons are searching for the neurons that need to be connected in the brain at the same time.
    How do they accurately locate their destinations? On September 21, 2021, the Liqun Luo Laboratory of Stanford University published a research paper titled Cellular bases of olfactory circuit assembly revealed by systematic time-lapse imaging in Cell
    .

    In this paper, Tongchao Li of Luo Liqun's laboratory and his colleagues used in vivo imaging to study the development of olfactory nerve circuits in Drosophila
    .

    The specific growth of nerves and the assembly of circuits are considered to be the core issues in the field of brain development
    .

    The biggest breakthrough of this research is the establishment of a live imaging system that can be used for the development of brain neural circuits in Drosophila, which will fill the gap between cell biology and genetics of brain neural development
    .

    In this study, the olfactory neural circuit of Drosophila was developed as a research system, and an in vitro culture system based on Drosophila antennae-brain was developed.
    Through high-resolution long-term in vivo imaging, 30 types of olfactory sensory nerve axons from the antennae were observed for the first time How does it grow to a specific area of ​​the brain
    .

    Their findings indicate that different types of olfactory sensory nerves adopt different strategies in the process of searching for the target area, showing the diversity of growth behaviors
    .

     The Luo Liqun laboratory collaborated with Professor Eric Betzig (Nobel Prize winner in 2014) and his postdoctoral fellow Fu Tianming from the Janelia Research Campus (Janelia Research Campus) to use an adaptive optics Correction (an optical correction technology derived from astronomical telescopes) is the MOSAIC microscope.
    They discovered for the first time a new subcellular structure exploring branch located at the end of axon, which is used for The target signal is detected when the end of the axon approaches the target
    .

     In addition, they found that when a nerve grows in the brain, it exhibits a completely different or even opposite cytoskeleton (a classic model from previous textbooks) when a single nerve grows in a petri dish
    .

    Their findings indicate that observations based on nerve growth inside the living brain are essential for understanding normal neural development
    .

    Using microsurgical operations to remove the unilateral olfactory sensory nerves during development, they also found that during development, the olfactory sensory nerves on both sides need to grow to the correct contralateral olfactory bulb, revealing the developmental process of the left and right hemispheres.
    Important synergies
    .

    The biggest breakthrough in this article is the establishment of a set of live imaging systems that can be used for the development of brain nerve circuits in Drosophila, which will fill the gap between cell biology and genetics of brain nerve development
    .

    Link to the paper: https://doi.
    org/10.
    1016/j.
    cell.
    2021.
    08.
    030, open for reprinting, welcome to forward to Moments and WeChat groups 
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