CELL: Dare to stay up late? Lack of sleep causes the intestines to accumulate reactive oxygen and die

Sleep is essential for survival, sleep behavior is everywhere, sleep-like conditions are evident in the earliest animals, and severe sleep loss can be fatalBut so far, the cause of the fatality is unclearrecently, researchers used fly and mouse models to find that sleep deprivation can lead to the accumulation of reactive oxygen species (ROS) and the resulting oxidative stress, especially in the intestinesROS is not only a contributing factor to sleep deprivation, but also a driver of death: THE neutralization of ROS prevents oxidative stress and allows flies to have a normal life with little or no sleepso we can fight the dangers of sleep deprivation by using oral antioxidant compounds or antioxidant enzymes targeted by the intestines that target genetically modified expressionstherefore, the researchers concluded that death after severe sleep restriction may be caused by oxidative stress, and that the intestines are the center of the process, and that no sleep survival is possible when ROS accumulation is prevented