 Home > Active Ingredient News > Antitumor Therapy > Cell Death Differ: arginine methyltransferase PRMT5: a potential therapeutic target for basal-like breast cancer

Cell Death Differ: arginine methyltransferase PRMT5: a potential therapeutic target for basal-like breast cancer

 Last Update: 2021-05-31
 Source: Internet
 Author: User

Tags

nattokinase cancer

cell healing

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Breast cancer is a common malignant tumor, which seriously threatens women's health.

The basal-like breast cancer (BLBC) subtype is characterized by the expression of basal markers rather than the status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (PR).

PRMT5 (Arginine Methyltransferase 5) is also an oncogene associated with a variety of cancers (including breast cancer).

PRMT5 interacts with KLF5 and methylates the latter

Knockout or drug inhibition (PJ-68) PRMT5 can reduce the expression level of KLF5 and its downstream target genes.

PJ-68 inhibits the growth of PRMT5 transplanted tumors

In summary, the results of this study reveal that PRMT5 can prevent its phosphorylation, ubiquitination and degradation by methylating KLF5, thereby promoting the maintenance and proliferation of breast cancer stem cells.

The results of the study revealed that PRMT5 can methylate KLF5 to prevent its phosphorylation, ubiquitination and degradation, thereby promoting the maintenance and proliferation of breast cancer stem cells.

org/10.

Leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

Dacarbazine CAS 4342-03-4 for Scientific Research Chemical Reagents Use only

CAS No.: 4342-03-4

Pharmacy Grade

$4-5/G FOB

Lapatinib 99% white powder CAS231277-92-2 bulk Lapatinib

CAS No.: 231277-92-2

Pharmacy Grade

$88-98/KG FOB

Mitomycin C

CAS No.: 50-07-7

Industrial Grade

$0.1/KG EXW

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

announcements today(81)

80 20 company(94)

united states logo(227)

single use technology(195)

healthy food name(42)

ups united states(221)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.