Cell Death Differ: Fra-2/AP-1 Lowers Fam212b expression to regulate the metastasis of melanoma cells

Metastasis melanoma is still one of the most challenging diseases, with poor clinical outcomes in patients.
some patients with metastasis melanoma benefit from the new treatment, the occurrence of metastasis is also associated with poor prognosis.
is a multi-step process involving the separation, migration, planting and survival of cancer cells in distant organs.
's current understanding of the signaling path paths that affect cancer cell metastasis.
, it is particularly important to understand the molecular mechanisms of how melanoma metasses.
the study showed that expression reduction in AP-1 transcription factor member Fra-2 in melanoma cells was associated with invasive melanoma estypes.
researchers found that knocking down fra-2 expressions in melanoma cells can cause elevated levels of Snail-1, Twist-1/2, and MMP-2 expression, and promote cell migration and aggression.
the expression of fra-2 in melanoma cell line can lead to increased lung and liver metastasis.
mouse melanoma cells knock low fra-2 increased lung metastasis and liver metastasis fra-2 knock-down melanoma cell metastasis potential increase may be caused by the acceleration of cell cycles and increased tissue angiogenesis.
the Fra-2 knock-down cell line microarray analysis, the researchers identified the Fam212b protein as a downstream target for Fra-2.
by further knocking down The Fam212b in Fra-2 mutant cells, the researchers found that fra-2 knock-down induced cell migration, invasion, and cell cycle transformation-related esogens were reduced.
addition, over-expression of Fam212b enhances the β-catenin signaling pathline, while expression of Fam212b is also associated with increased metastasis of melanoma in patients and poor clinical prognosis.
Fam212b is a new type of malignant melanoma biomarker, and the results reveal that the Fra-2/Fam212b pathline is a new path of melanoma metastasis, which may be a potential target for melanoma metastasis.
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