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    Home > Active Ingredient News > Digestive System Information > Cell Death Differ:PIWIL2 regulates the occurrence of autophagy and apoptosis of esophageal squamous cell cancer cells by interacting with IKK

    Cell Death Differ:PIWIL2 regulates the occurrence of autophagy and apoptosis of esophageal squamous cell cancer cells by interacting with IKK

    • Last Update: 2021-02-01
    • Source: Internet
    • Author: User
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    Esophageal cancer is the eighth most common type of cancer in the world and the sixth most common cause of cancer-related deaths.
    esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) are two common histological subsypes of esophageal cancer.
    ESCC is more common in East Asia, including China, while ESCCs are common in Western countries.
    As one of the most common malignant tumors in China, ESCC has a low five-year survival rate, which is also associated with the late diagnosis of the disease, frequent metastasis and the development of therapeutic resistance.
    previous studies have shown that inhibition of autophagy and apoptosis is critical to the survival of ESCC cells.
    molecular mechanisms have yet to be clarified.
    the study, where PIWIL2 was highly expressed in ESCC and associated with poor prognostication in patients, the researchers found that PIWIL2 was highly expressed in ESCC and was associated with higher stages and poor 5-year survival rates in patients.
    further studies have shown that PIWIL2 binds directly to IKK and promotes phosphorylation, which leads to phosphorylation of I-B and induces nuclear transport of NF-B, ultimately inhibiting apoptosis.
    ATIWIL2 regulates pattern maps of ESCC apoptosis and autophagy, the researchers found that PIWIL2 was able to competitively inhibit the binding of IKK to TSC1, inculcate the mTORC1 signaling path, and ultimately inhibit ULK1 phosphorylation and cell autophagy initiation.
    transplant tumor model reveals that PIWIL2 can promote ESCC growth in an IKK-dependent manner.
    , the results of this study reveal for the first time the role of PIWIL2 in regulating autophagy and apoptosis of cells, and the gene is also associated with adverse prognosis in ESCC patients, and the study also provides new insights into the role of PIWIL2 in tumor occurrence.
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