Cell Death Dis: High expression of cyclorapona Circ_0002770 indicates poor prognosis in melanoma patients

Melanoma, which often occurs in the skin, is a malignant tumor that originates in melanocytesAlthough melanoma accounts for only 3% of all annual cases of skin cancer, it accounts for more than 65% of the mortality ratemelanoma is a multi-factor tumor caused by the interaction between environmental exposure and genetic susceptibility, and exposure to UV rays is considered the most important risk factor for diseaseEarly detection and timely treatment are considered to be the two most critical factors in reducing melanoma mortalityringRNA (circRNA), characterized by a covalent closed-loop structure, is a new type of endogenous regulated RNA, which is widely found in mammalian cellsAlthough the complete pathogenesis of melanoma is not yet known, there is growing evidence that circRNA may be involvedin thein the study, researchers identified a cyclic RNA, circ_0002770, produced from the famous cancer gene MDM2, which has a sharp increase in expression levels in melanoma and is associated with a poor prognosis for the diseasethe expression of low circ_0002770 can inhibit the invasion, migration and proliferation of melanoma cellsThe mechanism study found that circ_0002770 can be used as a competitive sponge for miR-331-3p, indirectly regulating the expression of DUSP5 and TGFBR1Inhibition miR-331-3p can reverse the inhibition of si-circ_0002770 on the proliferation and invasion of melanoma cellsThe results of the physical experiment further confirmed that the expression of silent circ_0002770 can inhibit the formation of melanomain general, circ_0002770 can absorb and inhibit its function as a miR-331-3p sponge, while regulating the expression of DUSP5 and TGFBR1 to promote the proliferation, invasion and migration of melanoma cells