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Cell Death Dis: The expression level of BH3-only protein determines the response of hepatocellular carcinoma patients to sorafenib-based drug combination therapy

 Last Update: 2021-07-30
 Source: Internet
 Author: User

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Hepatocellular carcinoma (HCC) is a serious global health problem.

Recently, a combination therapy of atezolizumab (anti-PDL1) and bevacizumab (anti-VEGF) , an immune checkpoint inhibitor, has been approved as a first-line therapy for advanced HCC

immunity

Sorafenib and TRAIL-induced cell death

The researchers found that these two drugs can enhance the cell death effect induced by sorafenib, but this depends on the specific BH3-only protein

Sorafenib reduces the proliferation of Huh7 cells

All in all, the results of this study show that the expression of BH3-only protein determines the therapeutic response of HCC to different sorafenib drug combinations

The results of this study indicate that the expression of BH3-only protein determines the therapeutic response of HCC to different sorafenib drug combinations

BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment.

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