Cell Death Dis:miR-210-3p regulates the glycolysis in triple-negative breast cancer.

Breast cancer is one of the most common malignancies in women.
clinically, the expression status of PR (progesterone- and ER(estrogen-like) and HER2 (human skin growth factor liber2) is essential for the treatment of breast cancer patients.
-negative breast cancer (TNBC) refers to breast cancer that lacks PR, ER and HER2 expression.
reprogramming of energy metabolism is one of the hallmarks of cancer.
even under aerobic conditions, cancer cells exhibit glycolysis rather than oxidation phosphate, a phenomenon known as aerobic glycolysis, also known as the Warburg effect.
different from other breast cancer subtypes, TNBC showed high metabolic reprogramming, strong aggressiveness and lack of targeted treatment.
previous studies have shown that miRNA is essential to TNBC's malignant esopolymation.
little is known about miRNA's contribution to aerobic enzymes on TNBC.
, the three miRNAs of miR-210-3p, miR-105-5p and miR-767-5p were identified as significantly related to the Warburg effect in TNBC through comprehensive analysis and functional experiments.
researchers found that the expression of miR-210-3p can enhance glucose intake, lactic acid production, extracellular acidification rate, collection formation ability, and reduce serum hunger-induced apoptosis.
, the researchers found that GPD1L and CYGB were two functional regulators of miR-210-3p in TNBC.
mechanism studies have shown that miR-210-3p is able to target GPD1L to maintain the stability of HIF-1 alpha and to mediate CYGB to inhibit p53 activity, ultimately regulating the downstream glycolysis genes of HIF-1 alpha and p53 to promote aerobic glycolysis reactions.
, the study identified miRNAs that regulate aerobic enzymes and revealed that miR-210-3p had an important contribution to TNBC's Warburg effect.
.