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    Home > Active Ingredient News > Endocrine System > Cell Discovery: Guangzhou Health Center and others cultivate the world's first human permanent neonatal diabetic dog model

    Cell Discovery: Guangzhou Health Center and others cultivate the world's first human permanent neonatal diabetic dog model

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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    Recently, the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences cooperated with Beijing Sino Valley Biotechnology Co.
    , Ltd.
    to use a single-base editor to perform point mutations on glucokinase and successfully cultivated the world’s first human permanent neonatal diabetic canine model .
    The related paper " Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing" was published online in Cell Discovery
    .


     

    Recently, the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences cooperated with Beijing Sino Valley Biotechnology Co.


    Figure 1: Injection of exogenous insulin for permanent neonatal diabetes model dogs, homozygous mutant on the left, chimeric mutant on the right 

    Figure 1: Injection of exogenous insulin for permanent neonatal diabetes model dogs, homozygous mutant on the left, chimeric mutant on the right 

    Diabetes is the heart and vascular diseases and cancer after the third largest disease
    .


    At present, there are more than 400 million diabetic patients in the world, and more than 100 million diabetic patients in China


    Diabetes is the heart and vascular diseases and cancer after the third largest disease


    Obtaining an animal model that can accurately simulate the human disease is of great significance to the research on the mechanism of disease and the development of new treatment methods


    This study is the first attempt to use a single-base editor to perform point mutations on the canine GCK gene, so that the CAG codon on the GCK gene completes the C to T transition, thereby introducing a stop codon, terminating the translation of GCK early, and completely losing the GCK protein.


    GO enrichment analysis of the RNA sequencing results found that the permanent neonatal diabetes model dogs injected with exogenous insulin can promote the metabolism of lipids and fatty acids, so that the dog’s physiological indicators can be maintained at a relatively normal level, so that it can survive.


    Researcher Lai Liangxue of Guangzhou Institute of Biomedicine and Health Research of Chinese Academy of Sciences and Chairman Mi Jidong of Beijing Sino Valley Biotech Co.


    Original source

    Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing.


    Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing.
    Cell Discovery.
    2021.
    Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing.
    Cell Discovery.
    2021.
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