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【CELL DISCOV】The team of Tang Fuyi/Fu Wei used single-cell analysis to reveal the molecular basis of malignant phenotype and tumor microenvironment of small bowel adenocarcinoma

 Last Update: 2022-10-03
 Source: Internet
 Author: User

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This article is the original of the translational medicine network, please indicate the source when reprinting

Author: Mia

Small bowel adenocarcinoma (SBA) is a rare malignant tumor with high mortality, and the exploration of its molecular characteristics is currently lacking

On September 14, Tang and Fu Wei jointly published a research paper on Cell Discovery titled "Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas.

background

Small bowel adenocarcinoma (SBAs) are a rare type of gastrointestinal cancer with a poor prognosis

The incidence of SBA is lower relative to stomach cancer (GC) and colorectal cancer (CRC), but its intrinsic cause

Genomic studies have revealed different traits

Research overview

Due to limited knowledge and available data on the SBA, the research team used extrapolation of the CRC study as a primary reference for treating the SBA

First, the researchers identified 4 popular malignant cell subtypes: cell cycle program, mitochondrial program, metabolic program, and EMT program

In the tumor immune microenvironment, the researchers found a high correlation

scRNA-seq analysis reveals the cellular landscape of SBA

In addition, the researchers used scRNA-seq data from other published gastrointestinal cancers to compare the correlation between

The researchers also screened out 14 potential drugs for SBA treatment by using published omics and drug

Research summary

In summary, the study systematically analyzed the characteristics of malignant tumor cells and tumor microenvironment cells in SBA, revealing the tags of pathological phenotypes, the links between malignant tumor cells and microenvironmental cell tags, and drug

Resources:

This article is intended to introduce medical research advances and cannot be used as a reference for

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