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Disruption of the circadian rhythm in modern society has led to an increase in the incidence of metabolic diseases
biological clock biological clock immunity immunity insulin sensitivity digestion digestion
One specific AMP associated with host-microbe diurnal patterns is the regenerating islet-derived protein 3γ (Reg3γ)
In the present study, using a mouse model, the researchers found that distal SI Reg3γ circadian expression is not under CC control but is locally regulated by specific, diet-dependent oscillatory bacteria
Figure Reg3γ deficiency affects glucose homeostasis in a diet-dependent manner
Figure Reg3γ deficiency affects glucose homeostasis in a diet-dependent mannerIn conclusion, this study shows that the coordination of circadian rhythms is mainly influenced by diet and reciprocal sensory effect signals between host and microbial components, ultimately driving metabolism
references:
references:Frazier, K.
Frazier, K.
, Kambal, A.
, Zale, EA , Pierre, JF , Hubert, N.
, & Miyoshi, S.
, et al.
Western diet disrupts reg3γ and gut microbial rhythms promoting metabolic dysfunction.
Social Science Electronic Publishing.
https ://doi.
org/10.
1016/j.
chom.
2022.
03.
030
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