Cell interpretation! Revelation.

In a recent study published in the international journal Cell, scientists from New York University's Grossman School of Medicine and others found that nerve tissue may keep pancreatic cancer cells from starvation. In this
study, researchers focused on pancreatic catheter cancer (PDAC), one of the deadliest pancreatic cancers with a five-year survival rate of less than 10 percent, which stimulates the growth of deadly tissue, squeezing blood vessels and reducing the supply of blood-based nutrients such as serine, which can be used as an essential component of proteins and is essential for cancer cells to reproduce.
The researchers point out that hungry pancreatic cancer cells secrete a special protein called neurogenesis factor, which in turn sends signals to the extension of nerve cells to guide their growth deep in the tumor, an extension called axons that secretes serine, which frees pancreatic cancer cells from hunger and restores their growth.
researcher Alec Kimmelman said the study provides more evidence that pancreatic cancer is an extraordinary metabolic scavenger, which may help maintain its deadly properties; the ability of nerve tissue to transport nutrients from the blood to the harsh micro-environment of pancreatic tumors is a very meaningful adaptation that could hopefully help researchers develop new therapeutic methods to intervene in this unique flexibility.
researchers found that pancreatic cancer, which lacks serine, can use mRNA to convert information instructions into proteins, while mRNA's molecular skeleton- base decodes into amino acids using three base units called cryptonomes, and cell machines called ribosomes read each cryptoaccharide in the correct order when they are connected together, but the function of the nucleosome stagnates if there is no available amino acid.
surprised the researchers, they found that pancreatic cancer cells that were hungry for serine significantly slowed down the translation of two of the six serine codes (TCC and TCT) into amino acid chains.
In the case of serine hunger, this variability allows cancer cells to minimize the production of specific proteins, thereby preserving energy storage during hunger, but it continues to build stress-adaptive proteins such as neurogrowth factors (NGFs), which happen to be encoded by very few TCC and TCT cocoons.
NGF and other factors promote the growth of nerve tissue in pancreatic tumors and increase tumor growth, the researchers revealed for the first time that axons, as an extension of the nerve cells that transmit information, can provide metabolic support to cancer cells by secreting serine in nutrient-poor areas. In the
study, researchers described new ways pancreatic cancer cells look for energy, and in a 2016 study, researchers found that the cells sent signals to surrounding star cells, which helped them break down cell components into basic components that could be used by tumor cells, followed by a 2019 study that noted that pancreatic cancer cells The latest study, which intercepts a process called macropinocytosis, a physiological process in which normal cells pull nutrients from the outer membrane, has found that astrocytes and giant cells do not provide enough serine for cancer cell growth, which requires axons to transport.
researchers said that in PDAC mice fed a serine-free diet, tumor growth was observed to slow by 50 percent, and in order to exceed the effects of a diet alone, the researchers also used an FDA-approved method called LOXO-1. 01's drug to block axons is recruited into pDAC tumors, and the drug blocks the activation of the protein on the surface of neuron cells that interact with neurogen growth factors (TRK-A), thereby inhibiting the neuron's ability to deliver axons to the tumor.
This drug alone does not slow the growth of PDAC tumors in mice, but when used in combined with a serine-free diet, the tumor growth rate can be reduced by an additional 50 percent, suggesting that nerve tissue can support the growth of PDAC tumor cells in areas where serine is deprived.
researcher Robert Banh said that since TRK inhibitors have been approved for the treatment of certain cancers, in about 40 percent of patients with PDAC tumors that do not manufacture serine, it may be significant when combined with a hytacethystine diet after surgery;
: Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, et al. Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer, Cell (2020) doi:10.1016/j.cell.2020.10.016 (2) Nerves keeps pancreatic cancer cells from starving by NYU Langone Health From Bio Valley, for more information please download Bio Valley APP (2)