Cell interpretation! The most comprehensive study to date reveals the biological characteristics and pathogenesis of lung cancer in non-smokers!

July 30, 2020 /PRNewswire/ -- In a recent study published in the international journal Cell, scientists from the British Cancer Institute and others found that lung cancer in non-smokers tends to have diverse properties and appears to have different effects on targeted therapies than those in smokers.
many non-smoking lung cancer patients show signs of DNA damage caused by environmental carcinogens, especially young women who carry special genetic mutations that drive the cancer's growing malignancy, and the results may help develop new treatments for non-smoking lung cancer patients.
this study is also the most comprehensive study currently conducted by researchers on the biological characteristics of lung cancer in non-smoking populations.
photo source: James Heilman, MD/Wikipedia researchers analyzed tumor samples from 103 lung cancer patients in Taiwan, most of whom were non-smokers;
by studying genetic factors in tumor samples and related proteins produced by cancer cells, the researchers found that some of the early lung tumors in non-smokers are biologically similar to malignant diseases (lung cancer) in the smoking population, and that tumors in women's bodies typically carry special measures of the EGFR gene, although the most common errors in men are the KRAS and APC genes, which affect the response of men and women to targeted drugs.
screening of lung tumors in the early stages of late-stage scans may help develop more accurate anti-cancer therapies, and patients need to be closely monitored to analyze their progression; then researchers found genetic changepatterns involving the Family of APOBEC gene in three-quarters of tumor stakes in women under 60 years of age and women who do not carry the EGFR gene error, which plays a key role in the function of the immune system, but often by cancer Interception, which accelerates the emergence and evolution of cancer cell resistance, tends to be better performed in immunotherapy, and testing for APOBEC may also help screen female patients who are more likely to respond to this form therapy, and the researchers have selected a group of patients, especially older women, whose body cancers carry mutations associated with carcinogens in the environment, such as pollutants.
finally, researchers identified 65 overactive proteins in lung tumors that match current candidates, and found that proteins called MMP11, which cut off surrounding tissue, are often directly associated with poor prognosis in patients and can be a special marker for early diagnosis of lung cancer.
the researchers in this study focused on patients in Taiwan, they believe that the structure of the study applies equally to patients in the UK, and that they will conduct larger and not-only Studies in Asia later to confirm their findings.
researchers said that in this study, we analyzed the biological characteristics of lung cancer in a high proportion of non-smokers in the Asian population and found that the disease has a molecular diversity characteristic and is different from lung cancer in the smoking population.
researchers found different genetic patterns in non-smokers, men and women, suggesting that women who never smoked may have a different response to therapy than men who smoked; some early lung tumors also have special molecular traits, more like those found in advanced diseases, which may help researchers diagnose patients with advanced lung cancer more accurately and direct their clinical treatment.
the study, researchers gained a deeper understanding of the biological characteristics of lung cancer in people who never smoked, and also revealed new ways to effectively distinguish between patients with different tumor characteristics that could be used by customized therapeutic means.
lung cancer is the biggest cancer killer in the UK, and much of the cancer awareness stems from research into lung cancer in smokers, and the researchers hope that the results of this paper will actually improve the precise treatment of lung cancer in non-smoking populations in the future, providing patients with more accurate treatment options;
() Source: "1) Lung Cancer in non-smokers likely to different ly to treatment " 2) Yi-Ju Chen, Theodoros I. Roumeliotis, Ya-Hsuan Chang, et al. Proteogenomics of Non-smok-smok-Lung Cancer in East Asia Delineates Ses S. Of EGys and Progression, Cell (2020) doi: 10.1016/j.cell.2020.06.012.