Cell: Intestinal flora can change a variety of drugs, causing good drugs to become "poisons"

Recently, researchers at Princeton University solved the mystery by developing a systematic way to assess the transformation or metabolism of oral drugs in the gut: the different gut flora in the human body led to different reactions to the same drug, a widely effective drug that can become a deadly "poison" after it has been used by some people's gut floraThe report was published in Cell on June 11doi.org/10.1016/j.cell.2020.05.001the gut is a must for oral drugs in the human body, where hundreds of bacteria live, the coded genes are estimated to be 100 times the human genome, this huge diversity and richness suggests that there is a series of undescribed metabolic intake of chemicals biochemical activity, in contrast to previous studies of how an gut microbe metabolizes oral drugs, the new study looks at the entire gut flora and provides a more comprehensive and realistic understanding of the role of the gut microbiome in drug metabolism21 fecal samples collected by researchers from anonymous donorsThe types of bacteria living in each individual were classifiedMiraculously, each donor has its own unique microbiome in his or her gut, and most of these individual communities can grow in laboratory culture systems, the researchers developed a combination of biochemical and analytical chemistry and observed the metabolic response of these cultured microbiomes to 575 FDA-approved drugsOf the 438 effectively analyzed drugs, there were 57 examples of gut bacteria that could alter the efficacy of existing oral drugs, 80 per cent of which had not been previously detectedAt the same time, these drugs span 28 pharmacological categories and differ in chemical structurespecifically, changes to oral medications by intestinal flora include turning the drug into an inactive state, reducing the drug's efficacy, or turning the drug into a toxic form that increases the risk of side effectsIn addition, the researchers found that these microbial-derived metabolic reactions can be reproduced in mouse models, meaning that drugs for different populations could be developed in the futureconcluded, the team concluded: "Our framework identifies the interactions between different new drugs and gut microbiomes between individuals and shows how gut microflora can be used in drug development and personalized medicine."the first author of the report, Jaime Lopez of the Princeton Lewis-Sigler Institute for Integrated Genomics, says this is a conflicting case of medicine and ecology"The bacteria in these microbiomes help each other and influence each other's enzyme spectrumIf it wasn't for research in a flora, we would never have seen this in the future, doctors may be able to design different drugs based on each person's gut flora, and patients will no longer have to worry about the side effects of the drug, which safety issues may be addressed to some extent References: study sifs for gut microbiome to rt drug safety and efficacy.
[2] Personalized Mapping of The Metaboli Drug by The Human Gut Microbiome .' Gut Microbiome Potentially Make Some STys Toxic, Can Finds.