CELL: Intestinal flora limits virus transmission through biliacid-I IFN signal axis

the !---- chikungunya virus (CHIKV) is an emerging alpha virus that has infected millions of people, however, so far, we still know very little about the factors that regulate disease outcomesrecently, researchers found that in sterile mice or conventionally fed mice that deplete gut microbes with oral antibiotics, more severe CHIKV infections and spread occurred within one day of vaccinationchanges in themicrobiotic group alter the TLR7-MyD88 signal of plasma cell dendritic cells (pDCs) and passivate the systemic production of type I interferon (IFN)thus, circulating mononucleoblasts express less IFN stimulation genes and allow CHIKV infection to occur, the researchers found that a single bacterial species, Clostridium scindens, or its derived metabolites, secondary bile acid deoxycholic acid, could restore the type I IFN reactions that pDC and MyD88 depend on to limit systemic CHIKV infection and transmission to mosquitoesthus, symbiotic gut bacteria regulate levels of antiviral immunity and circulating alpha virus estolicvirus seisluds within hours of infection through the bile acid-pDC-IFN signal axis, which affects viral infection, transmission and potential transmission