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    Home > Active Ingredient News > Immunology News > Cell: It's heavy! After more than 30 years of scientists finally found the key cause of food allergies - the body's overactive food quality control system!

    Cell: It's heavy! After more than 30 years of scientists finally found the key cause of food allergies - the body's overactive food quality control system!

    • Last Update: 2021-01-27
    • Source: Internet
    • Author: User
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    January 18, 2021 // -- Food allergy incidents have increased dramatically in developed countries for more than 30 years, with up to 8 percent of children in the United States having potentially fatal immune responses to foods such as milk, nuts, fish and shellfish, and scientists have been studying to try to explain why.
    a popular theory is that food allergies arise because of the presence of natural pathogens such as parasites injected into the modern environment, which in turn makes the immune system, which evolves to respond to natural threats such as this, become oversensitive to certain foods.
    , in a recent study published in the international journal Cell, scientists from Yale University and other institutions came up with a broad explanation for food allergies: the overactivation of the body's food quality control system, a complex and highly evolved process. It can be used to protect the body from harmful food intake, however, the presence of unnatural substances (including processed foods), the presence of environmental chemicals (such as tableware detergents), and the absence of natural microorganisms often play a key role in disrupting the body's food quality control procedures.
    Photo Source: CC0 Public Domain theory promises to lay the groundwork for future development of therapeutic and preventive strategies for treating food allergies; researcher Ruslan Medzhitov says that until we fully understand the biological mechanisms behind it, we may not be able to de-design a way to effectively prevent or treat food allergies, and if you don't know how a normal car works, you may not be a good car mechanic.
    quality control system that exists in all animal body biology includes "sensory guardians" and if something smells or doesn't sing well, we don't eat it.
    And there are "sentinel" in the gut, which can be detected and excreted if we ingest toxins, and in the 3d case, the immune system's side-sensing nerves on the nervous system are mobilized to help eliminate the threat.
    Such immune system reactions can trigger allergic reactions, including food allergies, which in fact trigger the so-called "hygiene hypothesis" of food allergies, and the lack of natural threats such as parasites makes some immune systems highly sensitive and more likely to react to commonly harmless proteins present in specific food groups, which may help explain why people living in rural areas are less likely to develop food allergies than those living in urban areas.
    Medzhitov points out, however, that when parasites are eliminated from developed countries, food allergy rates in the population continue to rise sharply, so the researchers speculate that there may be other environmental factors that affect the body's natural food quality control system and promote the body's immune system to become highly sensitive to specific food allergens.
    factors may include increased use of sanitary products and overuse of antibiotics, and second, changes in diet, increased intake of processed foods, reduced intake of naturally grown foods, and changes in the composition of the gut microbiome, the researchers said.
    In the end, the introduction of food preservatives and environmental chemicals, such as dishwashing agents, or the introduction of new elements for monitoring the body's immune system, in short, these changes in the environment may effectively induce the body's food quality control system, so that the immune system reacts to food proteins as if it were reacting to toxic substances.
    Finally, the researchers say that food allergies are no different from many other diseases caused by abnormal versions of the body's normal biological reactions, and that understanding the biological mechanisms behind normal processes in the body, such as food quality control systems, may help researchers identify the culprits of not just food allergies, but also other diseases.
    () Originals: Esther B. Florsheim, Zuri A. Sullivan, William Khoury-Hanold, et al. Food allergy as a biological food quality control system, Cell (2021) doi:10.1016/j.cell.2020.12.007
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