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Cell Journal: High-fat diet may cause intestinal tumors

 Last Update: 2021-08-08
 Source: Internet
 Author: User

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In many organizations, obesity is an established risk factor for cancer

Obesity increases the incidence and mortality of many cancers, including bowel cancer

Intestinal epithelial cells are at the forefront of digestion and absorption, and are maintained by actively circulating Lgr5+ intestinal stem cells (ISCs) located at the bottom of the intestinal glands, which respond to dietary cues

Intestinal adaptation to HFD may involve multiple downstream effects of PPAR targets

Importantly, the induction of FAO is a common downstream and targeted feature of the HFD-induced PPARd/a program, which can be used to improve the dryness and cancer consequences of this obesity model

Reference

Miyeko D.

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