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Alzheimer's sign is gradually becoming known to the public as a degenerative disease of the central nervous system in pre-senility and old age
In the adult brain, the nerves that exist in the niche of the hippocampusStem cells maintain the function of nerve production throughout their lives
stem cell
Recently, researchers from the Netherlands Institute of Neuroscience Evgenia Salta and Bart De Strooper from the University of Leuven in Belgium have collaborated in the international academic journal "Cell-An article titled "Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease" was published online on " Stem Cell ".
stem cell
First, the researchers performed postmortem immunohistochemical analysis on the neuronal progenitor cells proliferating in the subgranular region of the dentate gyrus of the hippocampus in tissue sections of 10 non-dementia control individuals and 10 Alzheimer's disease patients, which confirmed that they are in AD Mid-adult neurogenesis was pathologically damaged, and it was confirmed in a mouse model that the brain pathological damage in AD was related to the level of miR-132 in the adult hippocampal neurogenic niche
Next, the researchers evaluated the positioning of miR-132 in the adult neurogenic niche, and confirmed that miR-132 can be recruited by adult neural stem cells and progenitor cells as part of the response to exercise or aging-related stimuli through fluorescence sorting technology .
Stem Cells Stem Cells
Finally, the researchers explored whether increasing the level of miR-132 can improve the AHN deficiency observed in Alzheimer’s disease mouse models.
stem cell
In conclusion, this article confirms that miR-132 is one of the most consistently down-regulated miRNAs in AD, an effective regulator of AHN, and plays a role in cell-autonomous pre-neurogenesis in adult neural stem cells and their progeny
miRNA stem cells
The findings confirm the significance of AHN in a mouse model of Alzheimer's disease and reveal the possible therapeutic potential of targeting miR-132 in neurodegeneration
