Cell Metab: Eat more n-3 and n-6 ​​polyunsaturated fatty acids can promote the anti-cancer effect mediated by iron death 

In the past decade, the contribution of different nutrients to the biosynthesis, bioenergy and antioxidant requirements of cancer cells has been extensively studied

In many of these studies, researchers have found that cancer cells can get what they need based on mutations and metabolic preferences driven by the microenvironment

The existing research results on the above issues are contradictory.

So far, there have been fewer strategies aimed at supplementing specific nutrients rather than restricting diet

Rich in n-3 and n-6 ​​polyunsaturated fatty acids can promote iron death-mediated anti-cancer effects

The results showed that in the acidic environment of tumors, n-3 and n-6 ​​polyunsaturated fatty acids (PUFA) selectively induced iron death of cancer cells

In addition, compared with a diet rich in monounsaturated fatty acids, a diet rich in n-3 long-chain PUFA significantly slowed the growth of tumors in mice , and this effect was further enhanced after taking DGATi or ferroproteinase inducers

Original source:

Emeline Diergeet al.