Cell Metab: High blood sugar turns immune cells into new coronavirus accomplices! Scientists have found that high blood sugar conditions accelerate the replication of the new coronavirus in mononucleoblasts/macrophages and inhibit Antiviral Immunity in T-cells.

In a recent paper published in Cell Metabolism, brazilian scientists published a paper showing that many "silly white sweet" immune cells may be used by the new coronavirus: after the new coronavirus damages the lungs, the mononucleoblasts/ macrophages that gather at the site of the damage may be used by the new coronavirus in a high blood sugar environment and become a virus "manufacturing plant"! The study found that the expression of angiotensin conversion enzyme 2 (ACE2) in mononucleic/macrophages increased, making it easier to be infected with the new coronavirus, due to the release of interferons caused by lung damage, the effects of high blood sugar, etc.
these immune cells are infected, metabolic reprogramming occurs, the supply can rely mainly on glycoenzyme, which not only releases more inflammatory media such as IL-6, increasing the risk of cytokine storms, but also accelerates the replication of viruses in immune cells, while also inhibiting the antiviral immune action of T cells.
good mononucleo-macrophage, so incarnate the patient's pig teammate and God opponent, widowed heartache ah.jpg virus and muastilate immune cells, double the difficulty has a large number of clinical evidence suggests that diabetes or elevated blood sugar, with the new crown patient patient serious illness and death risk increased significantly.
and recently The Lancet Diabetes and Endocrinology published a special review to more comprehensively analyze the effects of high blood sugar. Most experts
agree that people with diabetes or elevated blood sugar have a high risk factor because they tend to combine a variety of underlying health problems, such as high blood pressure, obesity, cardiovascular disease, and the arrival of the new coronavirus is fuelling the fire, further amplifying these problems, thus making the patient's prognostic condition worse.
on the surface of islet beta cells, there is also a new coronavirus can bind ACE2 receptors, so some patients who did not have diabetes, after the onset of new coronary pneumonia, developed diabetes symptoms, and even entered a severe diabetic ketoacidosis state.
and the use of anti-sugar drugs such as metformin may be associated with a reduced risk of death.
but these effects are the "one-way output" of the new coronavirus to diabetes and elevated blood sugar.
then diabetes and blood sugar rise, will also give the new crown virus a wave of reverse assistance, so that they are more easily happy to make waves? The team of Brazilian scientists who conducted the study noted that after being infected with the new coronavirus, the patient's lung immune characteristics included a significant concentration of mononucleic/macrophage, and decided to analyze the changes that occurred in those cells first.
genetic sequencing results showed that these cells had significant lying up in interferon pathway-related gene expression. it is normal
lung cells are harmed by viruses, they release cytokines to recruit mononucleogens/macrophages, and then immune cells initiate interferon pathways, which is normal.
but the team also found that interferons increase the expression of ACE2 on the surface of the agglometry, which is equivalent to exposing the break directly to the new crown virus! And after being infected with the new crown virus, mononucleic/macrophages will release more TNF-beta, IL-1 beta, IL-6 and other inflammatory cytokines, which is absolutely not good, after all, released more, the fate of cytokine storm sourfactors came.
the research team's culture at different blood glucose concentrations showed that THE level of ACE2 expression on the surface of mononucleosome/macrophage, the amount of IL-1 beta secreted, and the level of viral load in the cell were positively correlated with the blood glucose concentration in the medium.
in other words, if the blood sugar of patients with new coronary pneumonia rises, the mononucleoblasts in the body are more susceptible to infection with the new coronal virus, and the effect of promoting an inflammatory response is stronger, consistent with the team's conclusions that the direct extraction of cell analysis from the patient's body.
after all, synthetic virus is a energy-consuming work, the demand for blood sugar is also normal.
high blood sugar, ACE2 and IL-1 beta followed by high and after being infected with the new crown virus, single-core/macrophage will be significantly metabolically reprogrammed to allow the switch to glycoenzyme,which is the "signature action" of the new coronavirus found in this study.
H1N1 influenza virus or respiratory syncytial virus (RSV) infection, no similar condition sesame. further experiments
showed that the metabolism of glucose through glycoenzyme was a necessary condition for the replication of the new coronavirus in mononucleoblastation/macrophages.
hIF-1 alpha, regulated by the active oxygen of the cell mitochondria, plays a key role throughout the process, the team suggested that targeting HIF-1 alpha may have some value in the treatment of neo-coronary pneumonia.
infected mononucleoblasts/macrophages, and not just processing plants for viruses and inflammatory cell media, these pig mates/god rivals, and even other means to help.
team found that the infected mononucleoblasts / macrophages secreted IL-1 beta, can inhibit the proliferation of CD4 plus / CD8 plus T cells, while the Surface of T cells PD-1 expression will increase significantly, early into the exhaustion state, can not participate in antiviral immunity.
and infected mononucleoblasts can even directly induce apoptosis in the lungs! These infected mononucleosomes/macrophages are simply "two ghosts who hate more than ghosts".
many foreign scientists have read the paper, have been on social media to speak out, suggesting that everyone "at home to hide from the new crown can not eat the sea and drink, especially to eat less sugar and carbon water."
seems to insist on a healthy diet is right, high blood sugar to the new crown virus as an accomplice, it is almost the same as the mechanism of cancer promotion.
odd dot cake decided this to eat some healthy food, physical strength, after all, anti-epidemic is not yet relaxed time.
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