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Is it possible to have diarrhea if you eat too much fruit? Can intravenous fructose cause shock? Long-term fructose drink may get fatty liver? Is fructose really toxic? On August 19, 2020, the Fu Sun energy team at Tsinghua University's School of Life published a paper entitled Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance (Tricarbon Glycase Regulatory Fruit) Research papers on the potential of sugar fat synthesis and dietary fructose intolerance) systematically reveal for the first time the metabolic characteristics of fructose and the mechanism by which tricarbon sugar kinase TK affects the occurrence of non-alcoholic fatty liver and dietary fructose tolerance by regulating the metabolic flow of fructose.
study found that one of the biggest characteristics of fructose metabolism is "fast", and "fast" is the root cause of "poison".
study found that fructose metabolism is 5-10 times faster than glucose metabolism.
Fructose metabolism bypasses glycogen synthase and fructose phosphoric acid kinase, thus being able to drive straight into the triamcinate cycle, fatty acid synthesis, triphosphate synthesis, as well as glucose synthesis and pyrethroid phosphoric acid pathways.
addition, fructose metabolism can also effectively increase the expression of fatty acid synthesis genes, thereby further increasing the risk of fatty liver disease.
't really the fastest.
study found that if you knock out the key speed-limiting enzyme for fructose metabolism, tricarbon glyco kinase (TK), fructose can be imported more quickly into the TCA Cycle and then thoroughly oxidized.
reason for this is that fructose was originally distributed by TK four flat into a variety of downstream metabolic pathways, but without TK with the consequences of sugar is more imported into the phosphorylation pathway.
oxidation of fructose not only causes strong oxidative stress and inflammatory reactions in liver cells, but also leads to the collapse of fructose metabolism and poor intestinal absorption in small intestine cells.
end result, Tk-/- knockout mice would rather be hungry and thirsty than drink another drop of fructose water.
interesting that humans have selectively retained a low-activity TK enzyme on Eurasia as they walk out of Africa.
the old ancestors in temperations and cold tempers eat no fruit? Curious Jun may ask, if fructose is so special, why don't I drink fructose drinks will also gain weight? This relates to another very important finding of the study: in high-sugar cases, glucose is converted into resulting sugars, which are then promoted by fructose enzymes to promote the synthesis of fatty acids.
if the Tk gene was removed from the livers of mice, fatty livers in hereditary obesity (ob/ob) and high-fat-induced obesity mice (HFD) could be significantly improved.
, of course, their livers don't get any better because of fatty liver improvement, because oxidative stress causes a lot of inflammatory cell immersion.
the poison of fructose is really all-in! Zhujun may ask, if fructose is really so toxic, I do not have to eat less fruit ah? That's a good question.
study suggests that fructose plays a more "rewarding" role, with rapid metabolism giving people a sense of satisfaction.
how to eat more, eat a lot of good and bad things, we still have to consult nutritionists.
Lei, a 2015 graduate of Tsinghua University's School of Life Sciences, is the first author of this paper, and Li Tian and Liao Yilie, 2013 doctoral students at the School of Life, have made important contributions to the research.
was helped by a team of academicians from Tsinghua University's School of Life, Chen Weiguang, and a researcher from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences.
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