Cell Metabol: Acetate or the ability to regulate the function of immune cells to effectively eliminate pathogen infection.

11, 2020 // The concentration of acetate can increase dramatically at the site of infection in the body, and in a recent study published in the international journal Cell Metabolism, scientists from institutions such as the University of Basel in Switzerland found that acetate may support the function of specific immune cells and help eliminate pathogens safely and effectively.
Photo Source: CC0 Public Domain Immune Cells Protect the Body and Effectively Eliminate Pathogens when InfectionS Occur, while the Soldiers (Immune Cells) that Make Up This Team Perform Better only in enemy attacks, and the mixing of molecules and metabolites at the infected site plays a decisive role in how immune cells function.
researcher Christoph Hess snr points out that one of the important factors is the metabolite, acetate, in which we analyzed the effects of acetate on memory T cells, which ensure that the body produces effective protection against pathogen infections.
in the first stage of the reaction, the increase in acetate concentration promotes the lethal function of T cells, however, if their concentration exceeds a specific threshold, a protective mechanism will be activated to slow down the immune function of these cells and promote the production of anti-inflammatory medial, thus inhibiting the excessive immune response and the corresponding tissue damage generated.
researcher Balmer said the study is the first to illustrate the twin effects of the body's immune system, which is triggered by a metabolite, and acetate essentially plays a double-sided role, stimulating the body's immune function on the one hand and slowing the body's immune function in a timely manner.
the final researchers say that if we can understand how metabolites affect the body's immune system function at multiple stages of the immune response, we may be able to develop better treatments to treat chronic inflammation or autoimmune diseases in the body. Original origins from
: Maria L. Balmer, Eric H. Ma, Andrew Thompson, et al. Memory CD8, T Balance Cells Pro- and Anti-Eric-EricY Activity by Reprogramming Cellular Ace Tate Handling at at of The Domain, Cell Cell Cellsm (2020) 10.1016/j.c.