Cell Metabol: Unexpected!

Although the potentiating effect of exercise on neurogenesis has been extensively studied, the molecular mechanisms underlying this response are not well understood by researchers
.

Recently, in a research report titled "Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging" published in the international journal Cell Metabolism , scientists from the University of Queensland and other institutions found through research that a A mineral found in many foods, selenium may reverse the effects of a stroke on the body's cognitive abilities and enhance learning and memory in aging brains .

Although the potentiating effect of exercise on neurogenesis has been extensively studied, the molecular mechanisms underlying this response are not well understood by researchers

Image Credit: Pixabay/CC0 Public Domain

Image Credit: Pixabay/CC0 Public Domain

In the article, the researchers analyzed the effects of exercise on the aging brain and found that levels of a protein critical for transporting selenium in the blood may be elevated by physical exercise; for the past 20 years, scientists have known, Exercise may create new neurons in the brain, but they don't know the molecular mechanism; so scientists investigated whether dietary selenium supplementation might replicate the effects of exercise, and they found that selenium supplementation might increase the Generation of neurons in aged mice and improved cognitive function in their bodies
.

In the article, the researchers analyzed the effects of exercise on the aging brain and found that levels of a protein critical for transporting selenium in the blood may be elevated by physical exercise; for the past 20 years, scientists have known, Exercise may create new neurons in the brain, but they don't know the molecular mechanism; so scientists investigated whether dietary selenium supplementation might replicate the effects of exercise, and they found that selenium supplementation might increase the Generation of neurons in aged mice and improved cognitive function in their bodies
.

The production of newborn neurons decreased rapidly in aged mice, as in humans; when the mice were given selenium supplements, the production of neurons increased, which reversed the Cognitive deficits observed in aging mice
.

Selenium, an essential trace mineral absorbed from soil and water, is found in foods such as grains, meat, and nuts, with Brazil nuts being the highest levels

The production of newborn neurons decreased rapidly in aged mice, as in humans; when the mice were given selenium supplements, the production of neurons increased, which reversed the Cognitive deficits observed in aging mice

The findings may help scientists to develop novel therapeutic strategies to enhance cognitive function in the brains of people who are unable to exercise due to poor health or older age; however, selenium supplementation may not be considered a complete replacement for exercise, and Excessive intake of selenium supplements may be detrimental to health; a person eating a balanced diet of fruits, nuts, vegetables, and meat tends to have good selenium levels; but in older people, especially those with neurological diseases In the patient population, selenium supplementation may be beneficial
.

The findings may help scientists to develop novel therapeutic strategies to enhance cognitive function in the brains of people who are unable to exercise due to poor health or older age; however, selenium supplementation may not be considered a complete replacement for exercise, and Excessive intake of selenium supplements may be detrimental to health; a person eating a balanced diet of fruits, nuts, vegetables, and meat tends to have good selenium levels; but in older people, especially those with neurological diseases In the patient population, selenium supplementation may be beneficial
.

Taken together, our findings provide a specific molecular mechanism that may link exercise-induced systemic environmental changes to the activation of quiescent hippocampal neural precursor cells and their subsequent recruitment to neurogenic trajectories.
connect
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Taken together, our findings provide a specific molecular mechanism that may link exercise-induced systemic environmental changes to the activation of quiescent hippocampal neural precursor cells and their subsequent recruitment to neurogenic trajectories.
connect
.

Original source:

Original source:

Odette Leiter , Zhan Zhuo , Ruslan Rust, et al.

Odette Leiter , Zhan Zhuo , Ruslan Rust, et al.
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging , Cell Metabolism (2022).
DOI: 10.
1016/j.
cmet.
2022.
01.
005 Selenium mediates exercise -induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging