echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > "Cell Metabolism" A New Way to Regulate Blood Sugar Levels Independently of Insulin

    "Cell Metabolism" A New Way to Regulate Blood Sugar Levels Independently of Insulin

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    New molecular approach to control blood sugar and avoid insulin resistance

    The discovery of insulin 100 years ago opened the door to life and hope for millions of diabetic patients

    This study, published in the journal Cell Metabolism on January 4, 2022, shows that a hormone called FGF1 regulates blood sugar by inhibiting lipolysis (lipolysis)

    "Finding a second hormone that inhibits lipolysis and lowers blood sugar is a scientific breakthrough," said co-senior author, Professor Ronald Evans, chair of Dimes in the field of molecular and developmental biology

    When we eat, energy-rich fat and glucose enter the bloodstream

    Previously, the laboratory showed that injection of FGF1 can significantly reduce blood sugar in mice, and chronic FGF1 treatment can alleviate insulin resistance

    In the current work, the research team investigated the mechanisms behind these phenomena and the connections between them

    It is already known that insulin inhibits lipolysis through PDE3B, which is an enzyme that initiates a signaling pathway, so the research team tested a series of similar enzymes, and PDE3B is their first choice

    Gencer Sancar, a postdoctoral researcher in the Evans laboratory, said: "This mechanism is basically the second loop, with all the advantages of parallel pathways

    The discovery of the PDE4 pathway opens up new opportunities for drug discovery and basic research focusing on hyperglycemia and insulin resistance

    "FGF1's unique ability to induce continuous hypoglycemia in insulin-resistant diabetic mice is a promising treatment

    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.