Cell Metabolism: Metabolic vulnerability may be a new target for metastatic breast cancer

Metabolic differences may explain why some metastatic breast cancer cells rapidly develop tumors after they transfer from a primary tumor to the brain, while others develop these secondary The tumor lingers for months or years

Dr.

"Brain metastases are a major problem for breast cancer patients, and most of our existing treatments are not as effective

The brain is a common site for breast cancer metastasis, especially in patients with the HER2+ subtype of the disease

Dr.

Using an animal model developed in the Malladi lab, the researchers found that the metabolism of these different types of brain metastases differs significantly

In addition, the researchers also found that M-BM cells and Lat cells had higher amounts of the protein xCT, which mediates oxidative stress, compared to S-BM cells

Dr.

Bioluminescence images of latent and dominant brain metastases in mice

 Original title:

Metabolic diversity determines within breast cancer brain-tropic cells metastatic fitness