Cell: New study reveals how taurine helps stop bacterial infections

In a new study, researchers from the National Institutes of Health in the United States, while exploring the body's natural defenses against bacterial infections, found that a nutrient called taurine helps the gut recall previous infections and kill invasive bacteria such as Klebsiella pneumoniae, Kpn.
findings may help in finding alternatives to antibiotics.
results were published online January 15, 2021 in the Journal of Cell, under the title "Lyth trains the host for microbiota-enhanced resistance to pathogens."
scientists know that the gut microbiome ---th trillions of beneficial microbes that live harmoniously in our guts--- can protect people from bacterial infections, but little is known about how they can protect them.
scientists are studying the gut microbiome, looking to find or enhance natural remedies to replace antibiotics, which can harm the gut microbiome and become less effective as bacteria develop resistance.
the new study, the researchers observed that the gut microbiome, which had experienced previous infections and transferred to sterile mice, helped prevent infection with Kpn.
identified a class of bacteria---δ Deltaproteobacteria --- involved in fighting these infections, and further analysis led them to determine that taurine was the trigger for δ deformation bacteria activity.
helps the body digest fat, which is naturally found in bile acid in the gut.
sulfide, a toxic gas, is a by-product of taurine.
the researchers believe that low levels of taurine allow pathogens to be planted in the intestines, but high levels of taurine produce enough hydrogen sulfide to prevent them from planting.
During the study, they realized that a mild infection would be enough to prepare the gut microbiome against subsequent infections, while the liver and gallbladder -- which synthesize and store bile acids containing taurine --- can form long-term infection protection.
study found that adding taurine to drinking water also prepared the gut microbiome for infection prevention.
However, when mice drank water containing bismuth subsalicylate --- a common over-the-counter drug used to treat diarrhea and stomach discomfort--- the protective effect of infection decreased because radon inhibited hydrogen sulfide production.
: 1. Apollo Stacy et al. Infection trains the host for microbiota-enhanced resistance to pathogens. Cell, 2021, doi:10.1016/j.cell.2020.12.011.Scientists nutrients identify that helpspleds plucking from Bio Valley, for more information please download Bio Valley APP (