Cell: People to middle-term last, eat less is the hard truth!

2020, "after 90" 30 years old, "after 80" 40 years old.
you still looking forward to the end of the outbreak to go out and eat and drink?
the latest Cell study once again cold reminder: "people to middle-life last, eat less is the hard truth."
February 28th,
Zoology Institute,
Genomics Institute and other institutions published a paper in Cell, revealing the "seven-point satiety" to delay the aging of the internal molecular mechanisms.a group of rats, male and female, grew up in the same environment, eating the same food, drinking the same water.
the rats for 18 months, the equivalent of a human "year without confusion." From this moment on, their fates were divided.
The researchers randomly divided the rats into two groups: the first group was the "flying group" (control group), and the second group was the "dieting group" (experimental group), which received less food day by day and eventually stabilized at about 70 percent of the normal amount of food. It's also commonly known as "seven-point full."
is it "seven full"?
researchers believe this will ensure that rats have basic energy needs without making them eat too much to meet.
the last nine months, rats in the release and dieting groups basically lived to old age, equivalent to about 70 years of human age.
next, the scientists compared the "70-year-old" elderly rats, which had been released and dieted, in detail with a group of "little fresh meat" rats 5 months old (equivalent to 16 years of age in humans).
" dieting rats not only slimmed out visible to the naked eye, but various indications showed that they looked younger than their peers. Ma Shuai, one of the study's first authors, said.
using high-volume single-cell and single-core transcription group sequencing techniques, the researchers obtained transcription group analysis data for more than 200,000 single cells and nucleus. The data came from nine tissues:
Liver, Kidney, Skin, Brain, Aorta, Brown Fat (BAT), White Fat (WAT), Bone Marrow (BM), Muscle (SM)and more than 70 percent of the cells in the tissues of the released group were "abnormally" changed compared to "little fresh meat." It has the greatest effect on the aorta, white fat and brown fat.these results show that the aorta of these released groups of older rats is on the verge of "returning home".
In addition, in the tissue organs of aging rats:
immune cells
(e.g. neutral granulocytes and plasma cells, etc.) increased;
results show that increased multi-tissue immune inflammatory stress is an iconic feature of aging.
"inflammation" here refers to a stress response of the immune system to injury and infection, which usually helps repair damage and protects the body. But if the expression of the inflammatory gene suddenly or continuously increases, the immune system is fully alert and the body's normal functional structure is disrupted.
it's like, special times when everyone is in a state of readiness, but for a long time so nervous, no one can stand ah.
the same, long-term prepared tissue cells will strike, making people vulnerable to diseases such as heart disease, stroke and lupus erythematosus that seriously affect human health, as scientists have long confirmed.
after comparing the molecular network maps of the release group with the dieting group, the researchers reached a key conclusion: "Seven-point satiety" can effectively reverse the changes that aging causes to the immune system.
in particular, more than a quarter of the gene changes in the list of genes whose expression is affected by aging can be reversed by dieting, and these genes primarily encode regulatory proteins and transcription factors associated with inflammatory reactions and lipid metabolism.
high-profile protein, the S100A8 protein, has been shown to be closely associated with many inflammatory pathological processes, including asthma. The protein's content in the serum can increase significantly with aging, and dieting alone can significantly reverse this increase.
as the study progressed, the authors found that dieting did more than that.
if two cells want to communicate with each other, they have to create mating and receptors separately, and as they age, the expression of the receptors and receptors becomes disordered and eventually overloaded. Imagine when a few "activists" send out frequent messages, while other cells can't receive them, they just collapse in place.
best way to deal with information overload is to keep the "activists" talking. And if you eat only seven minutes full, the body will automatically shut them up.
sounds good, but what if you still can't control your mouth and want to eat?
, if you're young, you can be way willy for a little time!
after all, the rats were not confused in their lifetimes and began to diet.
to tell you clearly: young and eat more, after all, but also long body.
This is the first time that scientists have systematically analyzed the patterns of cellular and molecular changes in the body's aging at the multi-organ and multi-tissue levels, revealing not only that chronic inflammation is a common feature of aging in mammalian bodies and organs, but also that proper dieting can delay aging and even reverse a series of physiological indicators associated with aging.
" We also provide a new biological marker for early warning of aging, linked to humans, and perhaps we can look in the human blood for these key factors affecting aging, to explore whether humans meet this law, and then to use these factors as an indicator of assessment, to explore the effects of exercise, alcohol and other behaviors on aging. Qu Jing, co-author of the study and a
the Institute of Zoology, said. Guanghui, Qu Jing, a researcher at the Institute of Zoology,
Zhang Weiwei, a researcher at the Beijing Genomics Institute, and Juan Carlos Izpisua Belmonte, a professor at the Salk Institute in the United States, are co-authors. Ma Shuai, assistant researcher of Zoology Research Institute, Sun Shuhui, assistant researcher of
Institute of Biophysics, Geng Lingling, associate researcher of Xuanwu Hospital of Capital Medical University, and Song Moxian, researcher of
Animal Research Institute, are the first authors.
paper link: