Cell plocyticity: How fatty acids affect mitochondrial division.

Recently, gao Ping and Zhang Huafeng of the School of Life Sciences of China University of Science and Technology published a research paper entitled Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission online at EMBO Journal.
the study revealed that the head-to-head synthesis of fatty acids can affect mitochondrial division and thus regulate cell plocytes.
erypotent stem cells have the potential of self-renewal and differentiation into various types of somatic cells compared with differentiated somatic cells, so they have broad application prospects in disease treatment.
erythroid stem cells have unique metabolic phenotypes, such as sugar metabolism is more likely to be sugar-enzyme than aerobic phosphate, and metabolic pathways for multiple amino acids are more likely to be synthesized.
however, little is known about the role of lipid metabolic networks in the maintenance and access of stem cell erpotentity.
study found that lipid accumulation occurs in embryonic stem cells and in cell reprogramming, mainly due to the enhancement of fatty acids from the beginning.
further mechanism studies have found that Acc1-mediated fatty acids promote mitochondrial division through two mechanisms that affect cellular plurisity: (1) lipid synthesis consumes acetylCoA as a substrate in cells, thereby reducing the ubiquitin degradation caused by acetylation of mitochondrial split protein Fis1;
further confirmed that the regulatory path is also conservative in the human system.
the first time, the study established a regulatory path between fatty acid synthesis, mitochondrial division and cell fate, which is of potentially important guiding significance to the clinical study of pluripotent stem cells.
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