Cell: Progress in the study of the spatial structure of SARS-CoV-2 virus neutralizing antibodies

The SARS-CoV-2 infection is caused by the binding of the COVID-19 virus spike protein to the host receptor angiotensin-converting enzyme 2 (ACE2), and then the viral membrane fuses with the host membrane

The Charles S.

It is worth noting that these neutralizing antibodies can inhibit or enhance the membrane fusion and syncytial formation mediated by the spike protein, which is related to the chronic tissue damage of COVID-19 patients

The various cryo-electron microscopy structures of the Spike antibody complex reveal different binding modes, which not only block ACE2 binding, but also change the conformational cycle of Spike protein triggered by ACE2 binding

Studies have found that stable and different spike protein conformations can regulate the membrane fusion mediated by the spike protein, which is of great significance in the pathology and immunity of the COVID-19 virus

Original source:

Daniel Asarnow, Bei Wang, Wen-Hsin Lee, et al.