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    Home > Biochemistry News > Natural Products News > Cell Rep: attack cancer shield with cancer spear! Scientists have successfully used telomerase activity to kill tumors

    Cell Rep: attack cancer shield with cancer spear! Scientists have successfully used telomerase activity to kill tumors

    • Last Update: 2018-06-18
    • Source: Internet
    • Author: User
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    June 18, 2018 / Biovalley bio on / - highlights of this study: several nucleotide analogues (including 5-FdU) are effective substrates of telomerase; 5-FdU can induce a cell apoptosis dependent on telomerase activity; 5-fdutp can reduce the binding affinity of pot1-tpp1 to telomere DNA; 5-fdu-induced telomere DNA damage leads to the activation of RPA, CHK1 and p53 Photo source: xuehoo Zeng et al Telomerase is a DNA terminal replicase Telomerase in cancer cells will be activated to promote cell immortality Although this makes telomerase an attractive target in anticancer drugs, most of the methods to inhibit its activity have been proved to be ineffective in clinical Recently, scientists from Case Western Reserve University have used a completely different strategy to selectively promote the toxicity of drugs to cancer cells by using the activity of telomerase Relevant research was published in cell reports recently, entitled "administration of a nuclear analog promoters cancer cell death in a telomerase dependent maner" The researchers found that several nucleotide analogues, including 5-fluoro-2 '- deoxyuridine (5-FdU) triphosphate, can be effectively integrated into telomere DNA by telomerase Injection of 5-FdU can increase telomere induced damage, inhibit the binding of telomere proteins, activate ATR related DNA damage response and promote cell death in a telomerase dependent manner All in all, this study shows that telomerase and its activity can also be used to develop new anticancer therapies Reference: xuehoo Zeng et al Administration of a nucleus analog promotes cancer cell death in a telecom dependent maner, cell reports (2018) Doi: 10.1016/j.cellep.2018.05.020
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