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    Home > Active Ingredient News > Digestive System Information > Cell Rep: Early exposure to antibiotics affects health and longevity in later life

    Cell Rep: Early exposure to antibiotics affects health and longevity in later life

    • Last Update: 2021-09-10
    • Source: Internet
    • Author: User
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    The intestinal microbiota is composed of a diverse microbial ecosystem, and more and more evidences show that it plays a broad role in maintaining the homeostasis, metabolism and immunity of the intestine and the entire body


    Immune Antibiotic Diabetes

    These effects are particularly prominent early in life


    The administration of antibiotics in the early life of mice will induce a significant increase in the total mass and fat mass of the mice.


    So far, research investigating the link between gut microbiota and longevity has been limited to invertebrate model organisms


    In Drosophila, the increase in age-related mammalian bacteria has been shown to occur before the integrity of the intestinal barrier is impaired, pro-inflammatory cytokine levels increase, and lifespan is shortened


    Effects on the gut microbiota in early and late life may affect lifespan Effects on gut microbiota in early and late life may affect lifespan

    Recently, researchers studied the effects of antibiotic exposure early in life on healthy, normal feed-fed wild-type mice


    Antibiotic use affects the health and longevity of old age through the intestinal flora

    Antibiotic use affects old age health and lifespan through intestinal flora.


    After antibiotic exposure, two different low-diversity community types appeared in the mouse intestine.


    PAM II mice have impaired immunity, increased insulin resistance, and evidence of increased inflammation in old age, and shortened lifespan PAM II mice have impaired immunity, increased insulin resistance, and evidence of increased inflammation in old age , And shortened lifespan

    Therefore, the data of this study shows that after antibiotic exposure, differences in the composition of the gut microbiota have different effects on the health of the host and the lifespan of old age


    After antibiotic exposure, the difference in the composition of the gut microbiota has different effects on the health of the host and the lifespan of the host after antibiotic exposure, the difference in the composition of the gut microbiota has different effects on the health of the host and the life of the old age

    Original source:

    Miriam A.


    The composition of the gut microbiota following early -life antibiotic exposure affects host health and longevity in later life in this message

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