Cell Rep: Identify a key protein that regulates the estrogen cycle in a female body, RSK2.

August 14, 2020 // -- Scientists from Vanderburg University and others have discovered a key regulatory protein that regulates the body's estrogen cycle in a recent study published in the international journal Cell Reports entitled "RSK2 Maintenances Adult Estrogen Homeostasis by Resed ERK1/2-Mediated Director of Estrogen Receptor Alpha."
Photo Source: CC0 Public Domain oral contraceptives moderately increase a woman's risk of breast cancer, and birth control uses estrogen, a hormone that binds to the estrogen receptor alpha (ER-alpha, estrogenogenor alpha) to alter the reproductive cycle.
researcher Deborah Lannigan said RSK2 was a potential tumor-suppressing protein, and when comparing reproductive tissue in wild mice with mice that knocked out RSK2, we found that RSK2 may be critical to maintaining ER-alpha levels.
In an in-depth analysis of breast tissue staining in the mice tested, the researchers found that RSK2 maintained the receptor's self-balance and adjusted the body's estrogen cycle by reducing oxidative stress, and the researchers confirmed this finding in a female cohort study using oral contraceptives, which had relatively low levels of RSK2 in the study group compared to the control group.
'In this study, we found that RSK2 may be a key regulator of estrogen-induced organisms, using birth control pills that cause their expression to be reduced or increase DNA damage in the body's cells through oxidative stress, a common cause of cancer,' the researchers said.
original source: Katarzyna A. Ludwik, Zachary M. Sandusky, Kimberly M. Stauffer, et al. RSK2 Maintenances Adult Estrogen Homeostasis by Adding ERK1/2-Mediated Dreon of Estrogen Receptor Alpha, Cell Reports (2020). DOI:10.1016/j.celrep.2020.107931.