Cell Rep: Inhibiting special TLK kinases or activating the body's congenital immune system promises to help develop new cancer therapies.

August 15, 2020 // -- Tousled-like kinases (TLKs, Tousled-like kinases) play a central role in DNA repair and replication and are expected to be potential therapeutic for scientists to develop new cancer therapies In a recent study published in the international journal Cell Reports, scientists from the Institute of Biomedical Research in Barcelona and others found that inhibiting TLK may activate the body's congenital immune system, which is an important factor in the body's response to cancer.
: IRB Barcelona researcher Travis H. Stracker said: 'We believe that TLKs are a potential target for the development of cancer therapies, and we also want to gain a deep understanding of how TLKs work and how cells respond to lower levels of TLKs.'
Previously, researchers have observed that reducing the activity of TLK may make cancer cells very sensitive to certain therapeutic preparations, and now researchers have found that blocking TLKs can induce an alternative telomere lengthening system (ALT, telomere lengthening system) to maintain telomere lengthening system, which is a common path through many cancers, including malignant cancers such as glioblastoma.
researchers have found that activating the ALT path path line may stimulate the activation of the congenital immune system, potentially attracting immune cells such as macrophages and T lymphocytes.
Now, as scientists realize that congenital immune responses can affect the effectiveness of chemotherapy and immunotherapy, activation of congenital immunity in cancer has become an area of research that scientists are scrambling to study.
In DNA, not all regions have the same function, and some of the rest contain key genetic information that makes proteins, but other areas called isotromats have regulatory and structural functions, but these regions do not contain protein-producing genes, and the other effect of TLK inhibitions we observed in this study is that the compressed isotromromosomes may not be compressed, making them more susceptible to RNA-producing machines, which eventually lead to changes in the cell's components. Segura Bayona, a researcher at
, said the study could help us clearly understand previous observations that the removal of TLK promotes cell replication stress, which may help researchers better analyze the effects of eliminating TLK on cancer therapy.
original source: Sandra Segura-Bayona, Marina Villamor-Pay, Camille Stephan-Otto Attolini, et al. Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres, Cell Reports (2020). doi:10.1016/j.celrep.2020.107983.