Cell Rep: New Discovery! Macrophages and nerves "liver and bile photos" to help bone repair

Introduction:immunecells are obviously important in bone repair, but a new U.Sstudy has found that one major role in the repair process is macrophages (white blood cells)It "talks" with nerve fibers, cooperating with the enemy's attack, prompting the bones to heal, the University of Hopkins School of Medicine in the United States recently found that macrophages through inflammation to alert the immune system to foreign invaders, can make the nerve regeneration of the injured boneThe study was published in the Journal of Cell ReportsIn December 2019, a team of researchers at Johns Hopkins University School of Medicine demonstrated in mice that repairing fractures requires the production, growth and diffusion of nerve cells or neurons throughout the injured areaThey show that this partly depends on a protein called neurogrowth factor (NGF)Now, researchers have studied the process in greater depth to better understand how the nerves and immune system work with the NGF to regenerate nerves in bone repairMay 26, 2020, in a new study published in the journal Cell Reports, researchers again found in mice that the combination of the primary myogloin receptor kinase A (TrkA) and NGF proteins stimulates nerve control (supply ingested nerves) and then stimulates new bone growth at the injured siteSurprisingly, the most important NGF in this process is the macrophage (i.ewhite blood cells) that sends emergency reports to the immune system in the first placeThe macrophages alert the immune system through inflammation, allowing the "guardians" to immunize the foreign invaders, and then devour ingresss of the attackers' wreckage and kill themwhen a bone is injured, the NGF releases in large numbersThis activates the sensory nerve and allows it to grow into the injured tissue These sensory nerves play a variety of roles, acting as sentry, blowing the whistle of body pain, alerting the bones to broken bones, and acting as coordinators to regulate bone healing to determine the mechanism for repairing bones, the researchers removed the same small skull from each mouse By manipulating the steps of the NGF-TrkA signaling pathway in different mice, the team found that (1) the release of NGF is consistent with the beginning of nerve dominance; NGF (attracted by chemical signals released during inflammation), (4) increase in NGF will cause the formation of new nerves in injured tissues, and (5) ngF, which destroys the production of NGF, reduces nerve domination and impairs skull regeneration (6) NGF is the necessary neurotrophic nutrient seokto A) The computer tomography image shows the bone regrowth in the skull of the mouse 14 days after the injury (black dashed line is the original part of the removed bone) ;(B) bone repair image (the original part of removal is between the white arrow) shows the expression of NGF (green) ;(C) B in the high magnification image of the part represented by the dashed white box (the white dashed line in C is the edge of the healing bone) researchers say it is now known that nerve growth and bone repair are interconnected processes Knowing this, they may be able to find ways to maximize a person's innate healing power Developing new ways to improve bone healing will benefit many people, especially the elderly, who, after all, have a higher chance of falling than having a heart attack