Cell Rep: Revealing how cells react to the body's fasting?
Last Update: 2020-06-17
Search more information of high quality chemicals, good prices and reliable suppliers, visit
, June 9, 2020 /
PRNewswire/ -- Obesity level
s are rising in the UK today due to today's lifestyle and high-calorie diet, according to a study published in the international journalCell Reports, in which scientists from the University of Warwick and others have revealed the molecular mechanisms by which cells respond to fasting and activate stoking cells, researchers sayPicture Source: University of Warwick
Cause and effect is the highest obesity rate in Western Europe, with obesity rates more than tripleins over the past 30 years, and it is estimated that by 2050 more than half of the UK population will be obese, an important risk factor for increased morbidity and mortality, and the rapid increase in obesity is due to modern lifestyles, including high-calorie dietsintermittent fasting, inter-day fasting, and other forms of periodic calorie-restricted diets that have been popular over the past few years, cells use the autophagy process, the cell's self-circulating process, in response to fastingResearcher Professor Ioannis Nezis said: 'In this study, we revealthe the molecular mechanisms by which cells activate autophagy during fasting, and we have also found several proteins that are critical to the transcription of autophagy genesthese proteins, Sequoia, YL-1, and Sir2, interact with Atg8a, a protein associated with autophagy in the cytoplasm, which can recruit Atg8a in the nucleus to control the transcription of autophagy genes, and in this study, researchers reveal for the first time the key role played by the cytoplasmic protein Atg8aFinally, the researchers say understanding the molecular mechanisms of autophagy gene activation during fasting may help to activate the cellular autophagy pathway with interventions to maintain a normal weight and promote the body's health(BioValleyBioon.com)original origins:Anne-Claire Jacomin, Stavroula Petridi, Marisa Di Monaco, et al.
Regulation of The EOf Autophagy Genes by Atrep8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila,Cell Reports(2020) doi: 10.1016/j.cel.2020.107695
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to firstname.lastname@example.org
. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.