Cell Res: Can I eat in unlimited quantities when I see something delicious? The answer is no! Wang Liming of Zhejiang University reveals its potential mechanism

Feeling fullness is a vital survival skill for all animal species, including humans.
although many neuromodulating agents that regulate food intake have been found in fruit flies, the mechanism of satiety is still elusive.
a research paper published online by The Cell Research team entitled "A novel satiety sensors detectors are glucose and suppresses food consumption via insulin-production cells in Drosophila", which explores how neuropeptide energy systems communicate satiety to affect food consumption in fruit flies.
adhesive peptide (DTK) and its subject,TAKR99D, were identified as eating inhibitors in RNAi screening.
two pairs of DTK-plus neurons in the brain of fruit flies can be activated by an increase in D-glucose in the blood lymph and have an inhibitory effect on eating.
These DTK-plus neurons form a double synactic loop for insulin-producing cells through THE99D-plus neurons, a well-known eating suppressor that quickly activates and stops eating during food intake.
, the study found a new type of satiety sensor in the brain of fruit flies that detects specific circulating nutrients that in turn regulate eating, thereby reducing energy-stabilized neuromodulation.
sense of hunger and satiety is essential to ensure an appropriate and balanced intake of energy and essential nutrients.
in rodent models, several groups of healing neurons have been identified as satiety sensors, including those that express pro-opiomelanocortin and melanocortin-4 receptors.
these neurons in a variety of ways, including nutrients in the circulatory system, satiety and fat build-up, and accordingly inhibit food consumption.
of satiety can lead to obesity and other related metabolic diseases in humans.
fruit flies provide a simple and easy-to-handle model to study satiety, as key physiological and metabolic components are largely conservative between mammals and fruit flies.
-producing cells (IPC) in the brains of fruit flies are more studied in the study of eating behavior and metabolism of fruit flies.
due to the lack of KATP channels, IPC may not be able to directly perceive circulating glucose, but it can be indirectly perceived through other upstream neuron populations.
IPC can also detect other nutrients in the blood lymph, including branched chain amino acids contained in cellular autonomy, and fructose, which may be expressed in the brain as Crz's Gr43a plus neurons.
it is not clear how many feeding regulatory signals work with IPC to properly regulate feeding behavior, including NPF, Hugin, DTK, Atostatin A (AstA), drosulfakinin (DSK) and lecytosin (LK).
study, a systematic approach was taken to study the neural basis of satiety in fruit flies, particularly the involvement of neuropeptide signaling.
the study screened a group of neuropeptides in quantitative food consumption tests and identified a neuropeptide subject, TAKR99D and its associated ingredient DTK, as an effective food intake inhibitor.
study found that two pairs of DTK-plus neurons in the brain of fruit flies are activated by glucose in the blood lymph, which communicates satiety signals to the IPC viaTAKR99D-neurons.
the DTK-TAKR99D-IPC loop during food intake.
, silence and activation of this neural circuit have strong stimulating and inhibitory effects on food consumption, respectively.
, the study reveals a novel mechanism for the satiety and feeding regulation of fruit flies.
the similarities in metabolic rules between fruit flies and mammals, the study may also shed light on the structure of satiety mechanisms in mammals and how they are affected by metabolic diseases.
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